卵巢上皮癌组织中HLAⅠ类抗原和CD54的表达及临床意义

EXPRESSION AND CLINICAL SIGNIFICANCE OF HLA CLASS Ⅰ ANTIGENS AND CD54 IN OVARIAN EPITHELIAL CANCER

用免疫组化 Ｓ Ａ Ｂ Ｃ 法检测 Ｈ Ｌ Ａ Ⅰ类抗原和 Ｃ Ｄ ５４的表达。结果表明，卵巢上皮癌４４ 份标本中， Ｈ Ｌ Ａ Ⅰ类抗原和 Ｃ Ｄ ５４的表达率分别为 ５９０９％ 和４５５１％ 。Ⅲ～Ⅳ期的 Ｈ Ｌ Ａ Ⅰ类抗原阳性表达率显著低于Ⅰ～Ⅱ期；有淋巴结转移者显著低于无淋巴结转移者；肿瘤复发者显著低于未复发者。 Ｃ Ｄ ５４表达则与临床分期、组织分化、淋巴结转移、组织学类型及肿瘤复发无明显相关性，但无 Ｈ Ｌ Ａ Ⅰ类抗原表达而 Ｃ Ｄ５４表达的患者复发率显著升高。提示卵巢上皮癌可能通过降调 Ｈ Ｌ Ａ Ⅰ类抗原表达及改变 Ｃ Ｄ ５４的表达等机制逃避机体的免疫监视，检测 Ｈ Ｌ Ａ Ⅰ类抗原和 Ｃ Ｄ ５４的表达可能有有助于判断卵巢癌患者的预后。

Expressions of HLA class Ⅰ antigens and CD54 were determined by immunohistochemical technique. Relations between expressions of the two molecules and the clinical pathological parameters, and the tumor relapse were analyzed. The results showed that expression rates of HLA class Ⅰ antigens and CD54 were 59.09% and 45.45% respectively. HLA I expression rate in Ⅲ Ⅳ stage was lower than that in Ⅰ Ⅱ stage; in tumors of lymph node positive patients was lower than that of lymph node negative patients. In patients with tumors expressing HLA Ⅰ antigens recurrence rate was lower than that in patients with tumors deficient of HLA class Ⅰ antigens. No relation between the expression of CD54 and the clinical pathological characteristics was found. When analyzing the relation between expression of CD54 and tumor relapse, although no significant difference was observed, patients with tumors lacking HLA class Ⅰ antigens but expressing CD54 had higher relapse rate than patients with tumors coexpressing HLA class Ⅰ antigens and CD54. OEC cells may escape from the immune survilance of the host through downregulating expression of HLA class Ⅰ antigens and altering expression of CD54. Evalusion of expressions of HLA class Ⅰ antigens and CD54 may be helpful for judge prognoses of OEC patients.