外源性IP-10对流感病毒及呼吸道合胞病毒感染小鼠肺病理学影响

The effect of exogenous IP-10 on mice's pulmonary pathology induced by influenza virus and respiratory syncytial virus

目的研究γ干扰素诱导蛋白10(IP-10)对感染流感病毒或呼吸道合胞病毒(RSV)小鼠的肺部病理学变化的影响。方法对单纯感染流感病毒或RSV以及注射重组小鼠IP-10后再感染流感病毒或RSV小鼠的肺病理学变化进行比较,同时设正常对照组和仅注射IP-10对照组。结果注射IP-10后,感染流感病毒或RSV组小鼠出现严重肺部炎症,而单纯感染病毒组小鼠虽然也呈间质性肺炎表现,但病变程度远较前2组轻,差异具有高度显著性(t值分别为-12.56、-5.60,均P<0.01)。注射IP-10后,感染流感病毒组小鼠肺炎重于RSV感染组,两组间质性肺炎病理评分比较,差异具有高度显著性(t=7.73,P<0.01)。结论 IP-10对病毒所致小鼠肺部炎性病变,特别是对流感病毒性肺炎严重程度具有重要影响。

Objective To study the effect of γ interferon-indueible protein 10 （IP-10） on pulmonary pathological changes in mice infected with influenza virus （IV） or respiratory syncytial virus（RSV）. Methods Pulmonary patho- logical changes in mice infected with IV or RSV after being administered IP 10 were compared with mice infected with IV or RSV alone, normal control and only IP-10 administration mice were set up. Results The mice infected with IV or RSV after receiving IP-10 developed severe pulmonary inflammation, mice infected with IV or RSV alone also developed interstitial pneumonia, hut less serious than the mice infected with IV or RSV receiving IP-10, there were significant difference between the two respectively （t = - 12. 56;t = - 5.60, both P〈0. 01 ）. After being administered IP-10, mice infected with IV was more serious than the mice infected with RSV, there was significant difference in pathological scores of interstitial pneumonia（t = 7. 73, P〈0.01 ）. Conclusion IP10 is an important chemokine which has great effect on the severity of pneumonia caused by IV or RSV.