血清降钙素原在急性感染性疾病诊断中的应用

Diagnostic value of serum procalcitonin in acute infectious diseases

目的探讨血清降钙素原(PCT)在急性感染性疾病诊断中的应用价值。方法前瞻性纳入98例急诊发热患者,采血测定PCT、C-反应蛋白(CRP)及血常规,同时通过病原学或血清免疫学检测明确诊断,比较各指标对细菌感染的诊断价值。结果细菌感染组与非细菌感染组白细胞总数、中性粒细胞比值、PCT、CRP值比较,差异均有显著性,细菌感染组以上各指标均显著高于非细菌感染组(均P<0.01)。PCT诊断发热患者细菌感染的敏感性达91.30%,特异性82.76%,均高于其他指标。结论 PCT检测有助于鉴别急诊发热患者的细菌感染,且有更好的特异性及敏感性。

Objective To evaluate the clinical significance of serum procalcitonin （PCT） in acute infectious diseases. Methods Ninety eight emergency patients with fever were studied prospectively, then blood samples were taken to test PCT, C-reactive protein （CRP） and blood routine. Etiology or serum immunological tests were performed for diagnosis, the value of all test results for diagnosis of bacterial infection were compared. Results White blood cell, neutrophil ratio, PCT, and CRP in bacterial infection group were all higher than those of non-bacterial infection group （P〈0.01）. The sensitivity and specificity of PCT was 91.30% and 82. 76% respectively, and it had a higher diagnostic value than the other indicators in fever patients with bacterial infection. Conclusion PCT tests are helpful to identify bacterial infection in patients with fever, it has good sensitivity and specificity.