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舒尼替尼治疗耐伊马替尼胃肠道间质瘤的研究进展 被引量：3

Development of sunitinib in the treatment of imatinib-resistant gastrointestinal stromal tumors
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摘要 舒尼替尼是一个小分子多靶点酪氨酸激酶抑制剂，可抑制多个与肿瘤生长和血管生成相关的受体酪氨酸激酶。2006年被FDA批准用于不能耐受伊马替尼或治疗后疾病进展的胃肠道问质瘤（GIST）患者。本文拟就舒尼替尼在胃肠道间质瘤二线治疗中可能的分子机制、耐药机制、生物标志物、临床试验、不良反应及局限性等方面作一综述。 Sunitinib malate （SU11248, Sutent） is an orally available small-molecule muhitargeted tyrosine kinase inhibitor that has potent anti-angiogenic and antitumour activities. In 2006 sunitinib was approved by FDA for imatinib intolerant gastrointestinal stromal tumors （GIST） patients or imatinib resistant GIST pa- tients. This article review the molecular-based mechanism, the mechanism of resistance,the hiomarker, the clinical trials and the adverse effects of sunitinib in the treatment of imatinib-resistant GIST.
作者 王珂 丁克峰
机构地区 浙江大学医学院附属第二医院肿瘤外科
出处 《国际外科学杂志》 2011年第2期132-135,共4页 International Journal of Surgery
关键词 舒尼替尼 胃肠道间质瘤 耐药 Sunitinib Gastrointestinal stromal tumors Resistance
分类号 R735 [医药卫生—肿瘤]
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参考文献25

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同被引文献40

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国际外科学杂志
2011年 第2期

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