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孕妇尿中3种邻苯二甲酸酯类代谢物的含量及影响因素 被引量:9

Levels of Phthalate Metabolites in Pregnant Women and Influencing Factors
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摘要 目的了解孕妇的邻苯二甲酸二丁酯(di-n-butyl phthalate,DBP)、邻苯二甲酸丁基苄基酯(butylbenzylphthalate,BBzP)和邻苯二甲酸二(2-乙基己基)酯[di(2-ethylhexyl)phthalate,DEHP]3种邻苯二甲酸酯类(phthalate esters,PAEs)暴露情况。方法抽取某直辖市一所三级甲等医院2010年5—7月间入院且排除有PAEs职业接触的50名孕妇进行问卷调查,调查内容包括孕妇基本信息(如年龄、身高、吸烟饮酒史等)及孕期PAEs的暴露信息等内容。采用固相萃取(SPE)-反相高效液相色谱(RP-HPLC)法测定孕妇孕期尿液中DBP、BBzP、DEHP的代谢物(phthalate metabolites)邻苯二甲酸单丁酯(mono-n-butyl phthalate,MBP)、邻苯二甲酸单苄基酯(mono-benzyl phthalate,MBzP)和邻苯二甲酸单乙基己酯(mono-2-ethylhexyl phthalate,MEHP)的含量。采用多因素Logistic回归模型分析其主要暴露途径。结果孕妇尿液中MBP的检出范围为未检出~6 673.061μg/g Cr,中位数为19.487μg/g Cr,检出率为52.0%;MBzP的检出范围为未检出~6 227.937μg/g Cr,中位数为未检出,检出率为48.0%;MEHP的检出范围为未检出~2 139.802μg/g Cr,中位数为161.990μg/g Cr,检出率为78.0%。多因素Logistic回归分析结果显示,妊娠近期染烫发史、孕期使用化妆品和孕期饮食过程中使用塑料制品等因素是MBP暴露的危险因素(P<0.05),三者的偏回归系数分别是1.622、2.034和1.755;日常使用香水与妊娠近期染烫发是MBzP暴露的危险因素(P<0.05),二者的偏回归系数分别是1.921和1.771;近期进行室内装修(或更换家具)与孕期使用药物是高浓度MEHP暴露的危险因素(P<0.05),二者的偏回归系数分别是1.754和1.632。结论孕妇在日常生活中暴露于邻苯二甲酸酯类化合物。 Objective To analyze exposure levels of phthalate esters including di-n-butyl phthalate (DBP), butylbenzyl phthalate(BBzP) and di(2-ethylhexyl) phthalate(DEHP) in the urine of pregnant women. Methods Fifty pregnant women admitted in a municipal hospital were chosen during May to July 2010 to complete the questionnaires, ruled out occupational exposure to PAEs. The content included basic information (such as age, height, smoking and drinking history, etc.) and exposure of PAEs during pregnancy, etc. The concentration of three kinds of phthalate metabolites ( mono-n-butyl phthalate, MBP; mono-benzyl phthalate, MBzP; mono-2-ethylhexyl phthalate,MEHP) in urine samples were measured by using SPE reversed-phase high performance liquid chromatography. With collection of information on pregnant women's living environment by finishing questionnaires, major ways of exposure were analyzed by multivariate logistic regression. Results The levels of MBP in the urine of pregnant women ranged from undetected level to 6 673.061 μg/g Cr, and median of MBP was 19.487μg/g Cr, the rate of detection was 52%. The levels of MBzP ranged from undetected level to 6 227.937μg/g Cr, and median of MBzP was undetected, the rate of detection was 48%. The levels of MEHP ranged from undetected level to 2 139.802 μg/g Cr, and median of MEHP was 161.990 μg/g Cr, the rate of detection was 78%. Hair perm, using cosmetics and plastic products in diet significantly affected the detection of MBP (P〈0.05), and their partial regression coefficients were 1.622, 2.034 and 1.755 respectively. Meanwhile, hair penn and habit of using perfume significantly affected the detection of MBZP (P〈0.05), and their partial regression eoefficients were 1.921 and 1.771. New furniture or house decoration and using drugs were the risk factors for pregnant women exposed to high level of MEHP (P〈0.05), their partial regression coefficients were 1.754 and 1.632. Conclusion Pregnant women have been exoosed to ohthalates in daily life in the investigated area.
出处 《环境与健康杂志》 CAS CSCD 北大核心 2011年第1期1-5,共5页 Journal of Environment and Health
基金 天津市科技支撑计划重点项目(09ZCGYSF01700)
关键词 环境内分泌干扰物 孕妇 尿 邻苯二甲酸酯类 色谱法 高压液相 Environmental endocrine disruptors Pregnant women Urine Phthalate esters Chromatography, high pressure liquid
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参考文献12

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