电针对骨质疏松大鼠骨量及胰岛素样生长因子的影响

The Effect of Electro-acupuncture on Bone Quantity and Insulin-like Growth Factor in Osteoporosis Rats

目的:探讨电针对骨质疏松大鼠骨量及胰岛素样生长因子的影响。方法:将50只雌性未孕Wistar大鼠随机分为正常组、模型组、假手术组、雌激素组、电针组,采用双侧卵巢摘除术复制骨质疏松模型,造模成功后,治疗3个疗程,检测大鼠骨密度、骨矿含量及血清中IGF-1I、GF-2的变化。结果:骨质疏松大鼠BMD和BMC的含量明显降低,血清中IGF-1显著降低,与正常大鼠相比,有显著性差异;雌激素组、电针组大鼠BMD、BMC及血清中IGF-1含量明显增加,与模型组相比,有显著性差异。各组IGF-2变化不明显。电针组与雌激素组之间无显著性差异。结论:电针可提高骨质疏松大鼠骨量,可能是通过调节胰岛素样生长因子表达来实现的,其作用效果与雌激素作用效果相近。

Objective： To study the effect of electro - acupuncture on bone quantity and insulin - like growth factor in osteoporosis rats. Methods： 50 female Wister rats were randomly divided into control, sham operation, model, estrogen, electroacupuncture groups. After the bilaterally ovariectomized rats were made successfully and treated for 3 courses. The bone density and hepatic IGF - 1 ,IGF -2 were measured. Results： In the model group, BMD, BMC and IGF - 1 were significantly lower than that in the control （P 〈 0. 05 ）. BMD, BMC and IGF - 1 significantly increased in the two treatment groups after treatment. There was no significant difference between the estrogen group and the electro -acupuncture group. IGF -2 has no obvious change in the five groups. Conclusion： Electro- acupuncture influences insulin -like growth factor and bone quantity in osteoporosis rats.