应用外周静脉留置针输入奥沙利铂的临床观察

Clinical Observation of Infusion of Oxaliplatin by Peripheral Intravenous Detaining Needle

目的:观察外周静脉留置针输入奥沙利铂的外渗率。方法:104例胃肠道恶性肿瘤患者进行含奥沙利铂方案化疗,共完成592个周期。观察组用外周静脉留置针输入奥沙利铂480人次,对照组采用钢针输入奥沙利铂112人次,记录两种方法输入奥沙利铂的外渗情况。结果:用外周静脉留置针输入奥沙利铂外渗率为1.04%,钢针输入奥沙利铂的外渗率为21.43%,差异有统计学意义(P=0.000)。结论:应用外周静脉留置针输入奥沙利铂外渗率低,并且经济、安全、实用,值得临床推广应用。

Objective： To observe the exosmosls rate of intravenous infusion of oxaliplatin by peripheral intravenous detaining needle. Methods： 104 cases of gastrointestinal cancer accepted a total of 592 cycles of chemotherapy which containing oxaliplatin. The peripheral intravenous detaining needle was used in the observation group to infuse oxallplatin for total of 480 person-time while the needle was used in the control group for 112 person-time. Exosmosis rate was recorded in two groups. Results ： The exosmosis rate was 1.04% and 21.43% in observation group and control group respectively. The difference was statistically significant （P = 0. 000）. Conclusion： The application of peripheral intravenous detaining needle to infuse oxaliplatin gets low exosmosis rate. It is an economical , safe, practical way of infusion and worthy of clinical application.