高血压早期肾损害诊断指标的探讨

The laboratory diagnosis of renal early damage of the patients with essential hypertension

目的：探讨尿微量白蛋白（Ualb）、尿β2-微球蛋白（Uβ2－MG）、尿α1-微球蛋白（uα1-MG）和尿视黄醇结合蛋白（URBP）在高血压早期肾损害诊断中的价值及其敏感性。方法：Uβ2－MG、Ualb、Uα1－MG用放射免疫法测定，URBP用酶标法测定。结果：（1）高血压病人血肌酐（Scr）、血尿素氮（BUN）水平均正常，但Uβ2－MG、Ualb、Uα1－MG、URBP值均明显增高；（2）Ualb、Uαl－MG、URBP均优于Uβ2－MG，Ualb与Uα1-MG之间差异无明显意义。结论：Uβ2－MC、Ualb、Uα1-MG、URBP均可作为观察高血压早期肾损害的指标，其中Ualb、Uα1-MG、URBP较Uβ2－MG更好，URBP似乎更敏感。

Objective: to study urinary albumin(Ualb), Urinary al-microglobulin(Ua1 -MG ), Urinary β2 -microglobulin (Uβ2-MG), Unnary retinol-binding protein(LRBP) and compare with their value and sensitivity in detecting essential hypertension (EH). Methods: Ualb, Lα1-MG, Uβ2-MG were assaye by radioimmunoassay, LRBP by enzymed-linked immunosorbent assay(ELISA). Results: (1) Though serum creatinine (Scr), Blood urea nitrogen (BUN) were normal, the Ualb, La1 -MG, Uβ2-MG and URBP were higher than normal (2) in detecting renal early damage, Ualb, Ual -MG, URBP were superior to Uβ2-MG, there were no significant difference between Ualb and Ual-MG. lt seemed that LRBP was the most sensitive. Conclusion : Uaib Ual -MG, Uβ2-MG amd URBP may be used as markers of renal early damage in EH. The Ualb, Ua1 -MG and URBP are superior to Uβ2-MG,LRBP seems to be most sensitive.