活血化痰汤治疗冠心病(不稳定型)心绞痛及对降钙素基因相关肽的影响

Clinical Observation on the Therapeutic Effect of Kang Ning Hu Xin-Ⅱ on Stable Angina Pectoris

[目的]观察活血化痰汤治疗痰瘀阻滞型不稳定型心绞痛的临床疗效及降钙素基因相关肽的影响。[方法]不稳定型心绞痛患者60例,随机分为治疗组30例,对照组30例;对照组以西医基础治疗;治疗组在对照组治疗基础上加中药活血化痰汤300mL水煎服,日1剂早晚分服,疗程2周,观察两组在治疗前后心绞痛疗效及心电图改善方面的疗效变化及对降钙素基因相关肽(CGRP)的影响。[结果]治疗组与对照组相比较,能显著改善心绞痛患者的症状(P<0.05),改善缺血心电图(P<0.05)。治疗组对降钙素基因相关肽的影响优于对照组(P<0.05)。[结论]活血化痰汤能升高降钙素基因相关肽,明显改善临床症状及心电图。

[ Objective] To observe the effect of Huoxuehuatan decoction on calcitonin gens-related peptide on the patients with Unstable Angina Pectoris. [ Methods ] 60 patients were randomized to two groups. 30 patients as treatment group, in which a basic western medicine combine with Huoxuehuatan decoction. 30 pa- tients as control group, in which treat within which a basic western medicine combine be give. Testing the two groups in the treatment of angina pectoris before an after conventional ECG ST changes, changes in indicators of coagulation results and the blood samples which to determine blood sernm CGRP were increased in the morning just before and after treatment. [ Results ] The treatmen group compared with the control group, can sig- nificantly improve symptoms of patients with angina（ P 〈0.05） improvement in angina patients with ischemic ECG（P 〈0.05）. [ Conclusion]Huoxuehuatan decoction as a treatment for stable angina is obviously improve the clinical symptoms and electrocardiogram and increased CGRP.