节氧鼻导管的研制及其在氧疗中的节氧效率的观察

The study of oxygen conserving nasal cannula and evaluation of it′s oxygen saving ratio in treatment

目的 研制节氧鼻导管，并探讨其在慢性阻塞性肺疾病（ＣＯＰＤ） 患者中的节氧效率。方法 （１）利用吸气相给氧呼气相贮氧的原理，设计并制作节氧鼻导管；（２） 氧疗效果评定：在不同的氧流量（０－５、１－０、１－５、２－０ Ｌ／ｍｉｎ）下，采用随机、平行、交叉、对照方法，对节氧鼻导管及普通鼻导管氧疗２ 小时前后的动脉血气值进行分析，并监测氧疗后不同时间（１、３ 、５、１０、１５、３０、６０、１２０ ｍｉｎ）的经皮血氧饱和度（ＳｐＯ２）；（３）节氧效率评定：在不同的氧流量（０－５、１－０、１－５、２－０、２－５、３－０ Ｌ／ｍｉｎ）下，测定采用节氧鼻导管、国外同类产品、普通鼻导管氧疗５ 分钟前后的ＳｐＯ２ 值。结果 （１） 在不同的氧流量下，节氧鼻导管组氧疗２ 小时后，ＰａＯ２ 与ＳａＯ２ 值均较普通鼻导管组高（Ｐ＜０－０５）。（２） 在不同的氧流量下节氧效率分别为：氧流量０－５ Ｌ／ｍｉｎ 时节氧鼻导管的节氧效率为普通鼻导管的２－６ 倍；１－０ Ｌ／ｍｉｎ 时为１－８ 倍；１－５ Ｌ／ｍｉｎ 时为１－８ 倍；２－０ Ｌ／ｍｉｎ 时为１－５ 倍。（３） 节氧鼻导管与国外同类产品比较，节氧效率无显著差异（ Ｐ＞ ０－０５）。

Objective To study the oxygen conserving nasal cannula(CNC), and to evaluate it′s oxygen saving benefit ratio in COPD patients Methods (1)CNC was designed as a device which conserved oxygen during exhalation and given oxygen during inhalation; (2)Evaluation of the effect of oxygen therapy: blood analysis was measured at different flows of oxygen (0 5,1 0,1 5,2 0 L/min)before and after oxygen therapy The test is randomized ; Oxygen saturation(S pO 2) was measured at 1,2,3,5,10,15,30,60,120 minutes by pulse oximeter; (3) Evaluation of the oxygen saving benefit ratio : S pO 2 was measured at 0 5,1 0,1 5,2 0,2 5,3 0 L/min using CNC,the standard nasal cannula (SCN) and the new CNC Results (1) During two hours of oxygen therapy, the values of PaO 2 and SaO 2 in the CNC group were always higher than those in the SNC group ( P <0 05); (2) When the supply flow to CNC was set at 0 5 L/min, 1.0 L/min, 1 5 L/min, 2 0 L/min seperately, the oxygen saving benefit ratio of CNC to SNC was 2 6∶1, 1 8∶1,1 8∶1 and 1 5∶1 respectively. (3)The oxygen saving benefit ratio was comparable between CNC made in China and that made in foreign country Conclusions It was confirmed that CNC saved oxygen at different flows of oxygen, and the oxygen saving benefit ratio was higher at lower flows than that at higher flows