临床胰岛移植疗效分析

Analysis of the effect of clinical islet transplantation

本文对24例1型糖尿病患者行临床同种异体胎儿胰岛细胞移植治疗，对移植术后1～10年以上疗效进行分析。术前病人胰岛素用量为34～92U／d，经过术后不同时期的随访观察，较术前胰岛素用量减少，大部分患者均为50％左右（P＜0．01）。其空腹血糖基本维持在正常范围内。本组6例合并糖尿病眼底病变，术后有4例有不同程度好转。到目前为止，有的病例术后10年以上，仍未发现明显的功能减退。

We evaluated the result of human fatal is let allotransplantation in 24 patients with Type I diabetes mellitus 1 to more than 10 years after operation.The insulin requirement of patients were from 34U/d to 92 U/d before operation,after grafting,however,the doses of insulin reduced more than 50% in most of patients at different postoperative follow-up stage(P <0. 01).The fast glycemia basically maintained within normal range. Following operation, four of six patients concomitant with diabetic ocular fundus disease were seen making different degree of progress. UP till now,some of patients who underwent transplantation 10 years ago weren't found any marked decrease in graft function.