妊娠糖尿病患者血清CRP、IL-6、IL-8和UAlb水平的变化

Changes of serum CRP,IL-6,IL-8 and UAlb levels in cases with gestational diabetes mellitus

目的:探讨妊娠糖尿病患者血清CRP、IL-6、IL-8和尿微量白蛋白(UA lb)水平的变化及临床意义。方法:血清IL-6、IL-8和UA lb均采用放射免疫法、CRP则采用免疫散射比浊法测定。结果:血清CRP水平GDM组显著高于对照组,差异有统计学意义(P<0.01),G IGT组该指标水平略高于对照组,但差异无统计学意义(P>0.05)。IL-6水平GDM组高于对照组,差异有统计学意义(P<0.01),G IGT组水平亦高于对照组,差异有统计学意义(P<0.05)。IL-8水平GDM组高于对照组,差异有统计学意义(P<0.01),G IGT组水平亦高于对照组,差异有统计学意义(P<0.05)。UA lb水平GDM组显著高于对照组,差异有统计学意义(P<0.01),G IGT组水平略高于对照组,但差异无统计学差异(P>0.05)。结论:GDM组和G IGT组CRP、IL-6、IL-8和UA1b水平发生了不同程度的变化,测定其水平对于了解GDM的病情及评估预后有一定的临床意义。

Objective：To explore the changes and clinical significances of serum C-reactive protein（CRP）,interleukin-6（IL-6）,interleukin-8（IL-8） and urinary albumin（UAlb） levels in cases with gestational diabetes mellitus（GDM）.Methods：The levels of serum IL-6,IL-8 and UAlb were detected by radioimmunoassay,the level of serum CRP was detected by immunoturbidimetry.Results：The serum level of CRP in GDM group was significantly higher than that in control group（P0.01）;the serum level of CRP in GIGT group was higher than that in control group,but there was no significant difference（P0.05）;the serum level of IL-6 in GDM group was significantly higher than that in control group（P0.01）;the serum level of IL-6 in GIGT group was significantly higher than that in control group（P0.05）;the serum level of IL-8 in GDM group was significantly higher than that in control group（P0.01）;the serum level of IL-8 in GIGT group was significantly higher than that in control group（P0.05）;the serum level of UAlb in GDM group was significantly higher than that in control group（P0.01）;the serum level of UAlb in GIGT group was higher than that in control group,but there was no significant difference（P0.05）.Conclusion：The levels of CRP,IL-6,IL-8 and UAlb in GDM group and GIGT group change in different degree,the detection of their levels has a certain clinical significance in understanding the condition of GDM and evaluating the prognosis.