神经元特异性烯醇化酶测定在酒精所致精神障碍中的临床研究

The clinical research of neuron-specific endase on patients with alcoholism mental disorders

目的探讨酒精所致精神障碍的脑损伤程度;评估以戒酒、促脑细胞代谢为主的治疗方案的疗效;建立酒精所致精神障碍的生化诊断指标;为药物及心理治疗提供理论依据,提高治疗效果。方法采用酶联免疫吸附法对45例酒精所致精神障碍的患者治疗前以及治疗4周后进行血清中的NSE含量测定,并与45例正常对照组进行比较,同时对全部病例进行头颅CT检查以及BPRS和HRSD精神症状的评定。结果病例组血清中NSE含量明显高于对照组(P<0.05),病例组治疗4周后血清NSE含量比治疗前有所降低(P<0.05),病例组的CT检查异常率93.33%,血清中NSE含量与BPRS分值(r=0.588,P<0.001)、HRSD分值(r=0.581,P<0.001)均呈现正相关。结论检测血清中NSE含量,可以反映酒精所致精神障碍严重程度,评价治疗方案的疗效,还可指导临床用药。

Objective To explore the extent of brain damage,evaluate the curative effect of therapeutic project about temperance and the promoting metabolize of brain cell,establish the biochemistry and diagnostic index of alcoholism mental disorders,provide the academic gist of the pharmic and mental treatment,improve the therapeutic effect.Methods Serum NSE（with ELISA）levels in patients with alcoholism mental disorders（altogether 45 patients）and 45 controls,CT and the assessing of BPRS and HRSD evaluated.Results Serum NSE levels were significantly higher in patients with alcoholism mental disorders than those in the controls（P0.05）,and were higher than those in same patients after the 4 weeks treatment（P0.05）.The abnormal rate of the Brain CT was 93.33%.The relation of the serum NSE levels and the assessing of BPRS（r=0.588,P0.05）and HRSD（r=0.581,P0.05）were positive correlation.Conclusion The measure of serum NSE levels can response the serious degree of alcoholism mental disorders and evaluate the curative effect of therapeutic project,and instruct clinical administration.