高血压患者血清胰岛素、甲状旁腺激素及降钙素的测定和意义

The Determination of Insulin, Parathyroid Hormone and Calcitonin Levels in Patients with Essential Hypertension and Its Significance

测定２８例原发性高血压病（ＥＨ）患者和１５例健康对照者血清钙、甲状旁腺激素（ＰＴＨ）、降钙素（ＣＴ），计算 ＰＴＨ／ＣＴ比值，空腹葡萄糖（ＳＧ）、胰岛素（ＩＳ）和 Ｉ／Ｇ比值。结果：ＥＨ组 ＰＴＨ、ＰＴＨ／ＣＦ、ＩＳ和Ｉ／Ｇ高于对照组（均Ｐ＜０．０１）。血清钙和ＣＴ低于对照组（Ｐ＜０．０５，Ｐ＜０．０１）。单因子相关分析表明平均动脉压（ＭＡＰ）与ＰＴＨ、ＰＴＨ／ＣＴ、ＩＳ和Ｉ／Ｇ呈正相关，与血清钙、ＣＴ呈负相关。多因素逐步回归分析显示，ＰＴＨ／ＣＴ、Ｉ／Ｇ、ＰＴＨ与ＥＨ显著相关。

To investigate the relationship between essential hypertension(EH)and serum levels of glucose, calcitonin, in- sulin and parathyroid hormone. Metheds: Serum levels of fasting blood glucose(G), calcitonin(CT), insulin, parathyroid hor- mone(PTH)and calcitonin CT were determined in 28 cases of EH patients, 15 normal subject matched in age, sex and boby mass index were taken as control. At the same time, the ratios of I/G and PTH/CT were also calculated. Results: The levels of PTH, insulin and the ratios of PTH/CT and I/G were higher than those of normal controls. However, the levels of calcium and CT were lower than the control subjects (P < 0. 01, P < 0. 01, P < 0. 001, P < 0. 01 respectively) .The linear correlation analysis showed that MAP was correlated positively with PTH, the ratio of PTH/CT, insulin and the ratio of I/G(r = 0. 6130, P<0 .01, r = 0. 6710, P< 0. of, r = 0. 5028, P< 0 .05, r = 0. 5756, P < 0. 05), but correlated negatively with calcium and CT(r = - 0. 4128, P < 0. 05, r = - 0. 3760, P < 0. 01 ). Conclusion: Multiple regression analysis showed that ratios of I/G and PTH/CT might play an important role in the development of EH.