肺癌患者血清一氧化氮浓度变化的观察

A Survey of Nitric Oxide Content in Patients with Pulmonary Carcinoma

为了解肿瘤患者体内Ｎ０变化规律，应用萘乙烯二胺盐酸盐显色法对２５例健康人及１８例肺癌患者进行了血清ＮＯ含量测定，同时采用放射免疫法进行ＩＮＦ－α及ＳＯＤ平行测定。结果示：肺癌患者血清ＮＯ及ＴＮＦ－α含量明显高于对照组，而血清ＳＯＤ含量明显低于对照组。ＮＯ含量与ＴＮＦ－α及ＳＯＤ含量间不存在明显相关性变化。肺癌患者血清ＮＯ浓度随病情严重程度及病程延长而增加，与肿瘤病理分型无明显相关。

To find out how the change of nitric oxide(NO)is in patients with malignant tumor. Methods: The content of NO was measured by Griess development process in 25 controls and 18 patients with pulmonary carcinoma. To contrast with NO the contents of TNF-α and SOD, were determined simultaneously. Results: The levels of NO and TNF-α were remark- ably higher in patients with pulmonay carcinoma than in controls, but SOD, was significantly lower than in controls.There was no evident correlation between the NO and TNF-α Conclusion: The concentration of NO in patients with pulmonary carcinoma was increased along with stadium and exacerbation. The content of NO had no correlation with tumor's pathomorphological classification.