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靶向纳米探针介导的近红外激光热疗 被引量：2

Near-infrared Region Photothermal Therapy using Targeting Nanoprobe
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摘要 肿瘤靶向治疗的研究是当今生物医学界的研究热点。本研究采用整合素αvβ3单克隆抗体作为肿瘤靶向分子,以单壁碳纳米管(SWNT)作为运输裁体,同时利用单壁碳纳米管在近红外区的光吸收特性,开展靶向肿瘤光热治疗。实验结果表明,这种整合素αvβ3单抗标记的碳纳米管探针对高表达αvβ3的U87MG细胞具有高靶向选择性和靶向光杀伤性,能成为一种有潜力的靶向光热转换探针应用于新型肿瘤靶向治疗。 The pursuit of efficient and highly target-selective transporters is an active topic in cancer targeting therapy. Here, a novel functioned nanoprobe based on integrin αvβ3 monoclonal antibody labeled carbon nanotubes was developed to targeting and killing cancer cells under laser irradiation. The results revealed that the nanoprobe had a high efficiency in cancer cell targeting and killing in integrin αvβ3 positive U87MG ceils, could be used as a potential photothermal transductiou nanoprobe for cancer targeting therapy.
作者 周非凡 宋盛 吴宝艳 欧忠敏 邢达
机构地区 华南师范大学生物光子学研究院激光生命科学研究所
出处 《激光生物学报》 CAS CSCD 2011年第1期125-129,共5页 Acta Laser Biology Sinica
基金 科技部国家重点基础研究973计划项目(2010CB732602 2011CB910402) 教育部"长江学者与创新团队计划"创新团队项目(IRT0829) 国家自然科学基金项目(30870676 30870658 30800261)
关键词 肿瘤靶向治疗 碳纳米管 光热治疗 靶向探针 cancer targeting therapy carbon nanotubes photothermal therapy targeting probe
分类号 R73-362 [医药卫生—肿瘤]
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参考文献17

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二级参考文献20

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共引文献9

同被引文献28

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二级引证文献5

激光生物学报
2011年 第1期

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