泰山沙棘果抗炎镇痛及耐缺氧抗疲劳作用研究

Study on the anti-inflammatory effect,analgesic,anti-fatigue and hypoxia tolerance of Taishan Hippophae Rhamnoides fruits

目的:研究沙棘果的抗炎镇痛及耐缺氧抗疲劳作用。方法:二甲苯法和扭体法研究抗炎镇痛作用,游泳实验和耐缺氧实验研究抗疲劳及耐缺氧作用。结果:沙棘果提取物具有显著镇痛作用(p<0.01),水提物较醇提物效果明显,沙棘果醇提物有抗炎作用(p<0.05),而水提物作用不明显;沙棘果提取物能增强小鼠的抗疲劳能力和耐缺氧能力(p<0.05)。结论:沙棘果具有镇痛抗炎作用及增强小鼠耐缺氧能力和抗疲劳能力,且呈剂量-效应关系。

Objective： To study the anti-inflammatory and analgesic effect of extract of Hippophae Rhamnoides fruit and the effect on anti-hypoxia and anti-fatigue in mice.Methods： The rat ear edema induced by dimethyl benzene and writhing in rats to study anti-inflammation effect and analgesic effect,the hypoxia bearing was observed in experimental mice and the swimming test to study the anti-fatigue effect.Results： The extract of the Hippophae Rhamnoides fruit had analgesic effect（ p 0.01） ,and water extract was better than the alcohol extract,the alcohol extract had antifatigue effect （ p 0.05） and water extract hadn’t the effect,the extract of the Hippophae Rhamnoides fruit had hypoxia tolerance and anti-fatigue effect.Conclusion： The Hippophae Rhamnoides fruit had remarkable antiinflammatory effect,analgesic,antifatigue and hypoxia tolerance effect,and it had dosagedomino effect.