胆酸浙贝乙素酯的镇咳和祛痰药效学观察

Pharmacodynamic studies on antitussive and expectorant activities of cholic acid-verticinone ester

目的：研究胆酸浙贝乙素酯（CA—Ver）镇咳和祛痰的药效作用。方法：运用小鼠辣椒素引咳法、豚鼠枸橼酸引咳法、小鼠酚红排泌法和大鼠毛细管法来研究胆酸浙贝乙素酯在镇咳和祛痰方面的药理作用。结果：胆酸浙贝乙素酯6mg·kg^-1能极其显著地减少小鼠咳嗽次数；3、1．5、0．75mg·kg^-1剂量下均能剂量依赖地减少枸橼酸诱发的豚鼠咳嗽次数；3～6mg·kg^-1能极其显著地增加小鼠气管酚红的排泌量；1．5～3mg·kg^-1能够极其显著地增加大鼠气管痰液的排泌。结论：胆酸浙贝乙素酯可有效对抗辣椒素致小鼠咳嗽和枸橼酸致豚鼠咳嗽，并明显促进小鼠气道酚红排泌和大鼠痰液分泌量，具有良好的镇咳、祛疾活性，有很好的开发前景。

OBJECTIVE To study the antitussive and expectorant pharmacodynamic actions of cholic acid-verticinone ester （CA-Ver）. METHODS The antitussive effect of CA-Ver was evaluated by capsaicin-induced cough in mice and citric acid induced cough in guinea pigs. The expectorant effect was investigated by phenol red test in mice and capillary test in rats. RESULTS CA-Vet, 6 mg·kg^-1, significantly decreased the frequence of cough induced by capsaicin in mice; 3, 1.5, 0. 75 mg·kg ^-1 dose-dependently decreased the number of cough induced by citric acid in guinea pigs; 3- 6 mg·kg^-1 significantly increased the amount of phenol red （PR） secreted in mice; 1.5- 3 mg·kg^-1 also significantly increased the phlegm exudation of rats. CONCLUSION CA-Ver could inhibit capsaicin-induced cough in mice and citric acid-induced cough in guinea pigs. CAVer also increased phenol red secreted in mice and phlegm secretion in rat. CA-Ver deserves to pay much attention to its potent antitussive effects and has a good development perspective.