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t-复合多肽1基因在原发性肾病综合征患者外周血单个核细胞中的表达

Expression of TCP-1 in patients with primary nephrotic syndrome
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摘要 目的:初步探讨t-复合多肽1(TCP-1)基因在原发性肾病综合征(PNS)患者外周血单个核细胞(PBMC)中的表达及临床意义。方法:收集体检20例正常人(A组)和30例PNS患者(B+C组,其中B组为初发PNS患者,未用激素;C组为复诊PNS患者,使用激素2～3个月。各15例)的新鲜外周血液。用RT-PCR检测其外周血PBMC中TCP-1基因的表达。结果:A组分别与B+C组、B组、C组相比,TCP-1基因的表达差异均有显著性(P<0.01);B组与C组中的表达差异无显著性(P>0.05)。结论:TCP-1可能参与了PNS的发生发展过程。 Objective To explore the expression of t-complex polypeptide 1（TCP-1）in patients with primary nephrotic syndrome（PNS）and its clinical significance.Methods Fresh blood samples were collected from 20 healthy adults（group A）,and 30 PNS patients（group B ＋ C）,15 of whom received glucocorticoids for 2 to 3 months（group C）or no glucocorticoids（group B）.The expressions of TCP-1 in peripheral blood mononuclear cells were detected by RT-PCT.Results TCP-1 expression differed significantly between group A and group B ＋ C（P 0.01）,group B,or group C（P 0.01）;however,there was no significant difference between group B and group C.Conclusions TCP-1 may be involved in the pathogenesis and development of primary nephrotic syndrome.
作者 盛梅 曹灵 李霞斌 李瑶 孙兴旺
机构地区 泸州医学院附属医院肾内科 泸州医学院附属医院病理科
出处 《实用医学杂志》 CAS 北大核心 2011年第5期778-780,共3页 The Journal of Practical Medicine
基金 四川省教育厅重点项目(编号:2006A049) 泸州市科技局项目[编号:2007(64)-2]
关键词 肾病综合征 TCP-1 PBMC RT-PCR 糖皮质激素 Nephrotic syndrome TCP-1 PBMC RT-PCR Glucocorticoids
分类号 R692.3 [医药卫生—泌尿科学]
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参考文献11

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二级参考文献20

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实用医学杂志
2011年 第5期

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