奥扎格雷钠治疗急性脑梗死的临床研究

The Clinical Study of Sodium Ozagrel in Treating Acute Cerebral Infarction

目的观察奥扎格雷钠治疗急性脑梗死患者的疗效及治疗前后血液流变学变化。方法 80例急性脑梗死患者随机分为奥扎格雷钠组和川芎嗪组各40例,均静脉滴注给药。治疗组用氯化钠注射液500mL+奥扎格雷钠80mg,每日1次,对照组低分子右旋糖酐500mL+川芎嗪160mg,每日1次,连续应用14天为一疗程。治疗前后观察血液流变学指标及临床疗效、评价。结果治疗组明显高于对照组(P<0.01),且能降低全血高切粘度,低切粘度,血浆粘度,红细胞压积、纤维蛋白原等;头颅CT检查显示治疗组病灶较对照组有明显改善(P<0.01)。结论奥扎格雷钠治疗急性脑梗死能显著改善临床症状,降低血液流变学指标。

Objective To observe the effect of sodium of hemorheology pre and post treatment. Methods ozagrel in treating the acute cerebral infarction and the change Eighty patients of acute cerebral infarction were divided into two groups averragely at random the treatment group and the control group. The former were given 80mg sodium ozagrel solved in 250mL 0.9% sodium chloride, one time a day. And the latter were given 500mL low molecular Dextran with 160mg ligustrazine one time a day. Both were given the drug by intravenous drop for fourteen days.The index of hemorheology and the evaluation of clinical the rapentic effect were observed. Results The effect of treatment group was more significant than the control group（P〈0.01）, and the low and high-shear whole blood viscosity, plasma shear viscosity,hematocrit and fibrinogen were lowered down in infarction area also had an more significant improvement（P〈0.01）. symptoms in treating the acute cerebral infarction significandy and the treatment group. Cranial CT showded that the Conclusion Sodium ozagrel can improve the dinical lower down the index ofhemorheology.