摘要
目的研究微波提取白芍中芍药苷的工艺,得到优化工艺条件,建立芍药苷提取率与主要工艺参数之间的回归模型。方法采用正交设计法和微波提取,应用STATISTICA6.0统计软件对正交实验结果进行分析,分别考察粒径、乙醇浓度、液固比、时间、温度、微波功率的选择对芍药苷提取率的影响。结果优化工艺条件为粒径60目,乙醇浓度70%,液固比(mL.g-1)13,时间8 min,温度60℃,微波功率500 W。在此条件下,微波提取3次,芍药苷的平均提取率为2.225%。结论采用微波方法可优化白芍中芍药苷的提取工艺。
Objective To study the technology of extracting paeoniflorin from Paeonia lactif lora Pall by microwaveassisted extraction（MAE）. To establish the regression model between the yield ofpaeoniflorin and the major effecting factors. Methods The optimum extraction process was selected by orthogonal design. The results of the orthogonal experiments and the regression model were analyzed by STATISTICA6.0 software. Results The optimum extraction condition was explored as： particle diameter 60 mesh, ethanol-water composition 70%, solvent volume（ratio of solvent to solid） 13 mL·g^-1, extraction time 8 minutes, extraction temperature 60 ℃, power of microwave 500 W. Extracted for 3 times, and the average yield of paeoniflorin was 2.225%. Conclusion The technology process is stable and feasible. And it＇s suitable for industrial production of extracting paeoniflorin by MAE.
出处
《中国药物警戒》
2011年第3期141-144,共4页
Chinese Journal of Pharmacovigilance
关键词
芍药苷
微波提取
正交设计
paeoniflorin
microwave-assisted extraction
orthogonal design
