帕瑞昔布钠超前镇痛在银质针疗法中应用

A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED STUDY OF PREEMPTIVE PARECOXIB SODIUM:EFFECT ON PAIN DURING SILVER NEEDLE TREATMENT

目的:探讨帕瑞昔布钠超前应用在银质针疗法中的有效性与安全性。方法:120例腰腿痛患者随机分为两组:帕瑞昔布钠组(n=60)和对照组(n=60)。穿刺前30min给药,运用VAS法记录患者的疼痛评分,记录两组穿刺完成时间,穿刺过程中因疼痛影响穿刺的患者数量,穿刺前、穿刺时和拔针后1h的VAS评分,拔针后1h患者对镇痛总体满意度及整个治疗过程中的不良反应。结果:两组患者一般资料方面差异无统计学意义(P>0.05)。穿刺时疼痛、拔针后疼痛、患者满意度方面帕瑞昔布钠组明显优于对照组(P<0.05)。结论:帕瑞昔布钠用于银质针疗法中具有超前镇痛作用。

Objective： To investigate whether preemptive administration of parecoxib sodium would influence the reported pain procluced by the interventional technique itself.Methods： 120 patients with lumbocrural pain were randomly allocated into two groups： parecoxib sodium（n=60） and placebo（n=60）.The degree of pain was measured using visual analog scale（VAS）.Duration of the procedure,the number of patients whose movement interfering the procedure,patients＇ satisfaction after the puncture and the adverse effects were recorded.Patients＇ reported VAS of one hour before puncture,during puncture and one hour after the removal of the silver needle were recorded.Results： The demographic data were similar in the two groups.Procedural pain and pain after the puncture were significantly decreased with parecoxib administration in comparison with placebo（P0.05）.Patients＇ satisfaction was greater with parecoxib sodium in comparison with placebo.Conclusion： Parecoxib sodium can be safely used in the silver needle therapy and it shows a good analgesic effect.