巴玛益百软胶囊改善睡眠的实验研究

An experimental study of Bamayibai soft capsules assisting in improving sleep

目的:研究巴玛益百软胶囊改善睡眠的作用。方法:通过直接睡眠试验、延长戊巴比妥钠睡眠时间实验、戊巴比妥钠阈下剂量催眠实验、巴比妥钠睡眠潜伏期试验,观察诱导小鼠的睡眠作用。结果:分别以0.34 g/kg bw、0.67 g/kgbw、2.00 g/kg bw(相当于人体推荐用量的5、10、30倍)剂量的巴玛益百胶囊内容物连续给小鼠灌胃30 d,能延长戊巴比妥钠睡眠时间(P<0.05)、缩短巴比妥钠睡眠潜伏期(P<0.05),无直接睡眠作用,对小鼠的体重无影响。结论:本实验提示巴玛益百软胶囊具有改善睡眠功能作用。

Objective：To evaluate the effects of Bamayibai soft capsules on improving sleep.Methods： Direct inducing sleep test,the test of lengthen the sleep time that induced by pentobarbital sodium,the test of pentobarbital sodium subthrehold-hypnosis and the test of barbital sodium sleep latency were conducted in the study to observe the inductive effective of capsule contents.Results： Mice were fed with capsule contents at the dosage of 0.34 g/kg bw,0.67 g/kg bw and 2.00 g/kg bw for 30 days,and the results showed that the content could lengthen the sleep time that induced by pentobarbital sodium（P0.05） and shorten the barbital sodium sleep latency（P0.05）.No direct inducing sleep was showed and no effect on mice′s weight.Conclusion： The bamayibai soft capsules are effective on improving sleep.