杭州地区个体从业人员亚临床甲状腺功能减退症的调查分析

Screening analysis for subclincal hyPOthyroidism in independent merchant

目的：了解个体从业健康体检人员亚临床甲状腺功能减退症（SCH）的检出率,并观察SCH血清促甲状腺激素（TSH）与血脂的关系。方法：选取2007年个体从业健康体检人员血清2958份,采用化学免疫分析法测定TSH、游离三碘甲状腺原氨酸（FT3）和游离四碘甲状腺原氨酸（FT4）。血生化指标采用全自动生化检测仪测定。结果：2958例SCH总检出率7.03%。其中女性检出率8.95%,男性检出率4.79%,女性检出率高于男性（P〈0.01）。从年龄结构看：50岁~59岁组检出率最高11.73%,其次是18岁~29岁组和60C以上岁组。TSH与血脂相关因素中,男性TSH与尿酸（UA）呈正相关,与载酯蛋白A（APOA）呈负相关。结论：我科个体从业健康体检人员SCH总检出率较上海（6.1%）、南昌地区（6.1%）高;SCH的发生与年龄和性别相关;TSH血浓度对血脂的影响因性别不同而不同。

Objective：To investigate the prevalence of subclinical hypothyroidism（SCH） in independent merchant.Methods： Serum levels of TSH,FT3 and FT4 by chemilumino-immunoassay and lipid profile in 2958 subjects were determined in independent merchant.Results： The overall SCH prevalence was 7.03%.The SCH prevalence was significantly higher in females（8.95%） than in males（4.79%）.The relationship between the SCH prevalence in the sex and the age showed that the highest SCH prevalence was in the 50 years old group（11.73%）,the followed by 18 years old group（7.42%） and the 60 years old group（7.37%）.Serum TSH was closely in postive corelation to plasma UA levels in males（P0.01）,serum TSH was closely in nagetive corelation to plasma APOA levels in this group.Conclusion： The SCH prevalence is higher in independent merchant than Shanghai,Nanchang area.The serum TSH levels in famels and mels have a different effect on lipid.