四联递进联合治疗复发性细菌性阴道病167例临床观察

Clinical observation on 167 cases with recurrent bacterial vaginosis treated with quadruple progression therapy

目的：观察四联递进治疗复发性细菌性阴道病疗效。方法：将张掖医学高等专科学校附属医院诊断为复发性细菌性阴道病的患者（排除妊娠和哺乳期患者）383例,随机分为两组。试验组进行四联递进联合治疗,对照组常规药物治疗,观察两组疗效、疗程,阴道菌群调整、副作用、复发率情况。结果：治疗组有效率为98.20%,对照组为82.87%。治疗组平均治疗时间为5.7天,对照组平均16.8天,治疗组疗程明显短于对照组。治疗组使用乳酸菌素片,明显提高了阴道乳酸菌量,改善了阴道内环境。经过13年随访,治疗组复发率7.18%,对照组复发率65.74%,治疗组复发率明显低于对照组。结论：四联递进疗法治疗复发性细菌性阴道病疗效好,疗程短、治疗器械简单、复发率低。

Objective： To observe the clinical efficacy of quadruple progression therapy in treatment of recurrent bacterial vaginosis. Methods： 383 patients （excluding pregnant women and the patients at lactation period） diagnosed as recurrent bacterial vaginosis in the hospital were divided into two groups randomly, the patients in study group were treated with quadruple progression therapy, and the patients in control group were treated with conventional drug therapy ; the clinical efficaeies, courses of treatment, adjustion of vaginal flora, adverse reactions and recurrence rates in the two groups were observed. Results： The effective rates in treatment group and control group were 98.20% and 82. 87% , respectively; the average treatment times of treatment group and control group were 5.7 days and 16. 8 days, respectively, the course of treatment in treatment group was significantly shorter than that in control group; lactobacillin tablets were used in treatment group, the therapy increased the amount of lactobacillin and improved the vaginal internal environment ; after follow - up for 1 - 3 years, the recurrence rates of treatment group and control group were 7. 18% and 65. 74% , respectively, the recurrence rate of treatment group was significantly lower than that of control group. Conclusion： The clinical efficacy of quadruple progression therapy is good in treatment of recurrent bacterial vaginosis, the course of treatment is short, the therapy is simple with low recurrence rate, and it can maintain microflora balance.