帕瑞昔布钠超前镇痛对鼻内镜术后镇痛效果

Effect of Parecoxib Sodium for Preemptive Analgesia on the Postoperative Analgesia Used by the Nasal Endoscope

目的:研究帕瑞昔布钠超前镇痛对鼻内镜术后镇痛的效果。方法:选择ASAⅠ或Ⅱ级择期行鼻内镜手术的成人患者60例,随机分为帕瑞昔布钠超前镇痛组(A组)、帕瑞昔布钠术后镇痛组(B组)和对照组(C组)。A组在诱导前15 min注射帕瑞昔布钠40 mg;B组在手术结束后注射同等剂量帕瑞昔布钠;C组为对照组。采用视觉模拟评分和舒适评分评估术后1、2、4、8、12和24 h的镇痛效果和患者满意度。结果:术后1、2、4、8 h VAS A组低于B组(P<0.05);1、2、4、8 h各个时点的VAS C组均高于A组和B组(P<0.05);术后1、2、4、8 h BCS A组高于B组(P<0.05);1、2、4、8 h各个时点的BCS C组均低于A组和B组(P<0.05)。结论:帕瑞昔布钠超前镇痛用于成人鼻内镜术后镇痛,效果确实,不良反应少。

Objective：To study the preemptive analgesic effect of parecoxib sodium on postoperative analgesia used by the nasal endoscope. Method：60 adult patients undergoing nasal endoscope operations were randomly divided into three groups. The patients in Group A were injected intravenously with parecoxib sodium 40mg 15 minutes before intubation, and those in Group B were injected intravenously with parecoxib sodium at the end of the operation, and Group C was the controlled group. The analgesic effects were evaluated with VAS and BCS scores at 1,2, 4, 8 ,12 and 24 h after surgery. Result：VAS scores of Group A were lower than those of Group B at 1, 2, 4 and 8h （P 〈0.05）, and VAS scores of Group C were higher than those of Group A and Group B at those hours （ P 〈 0.05 ）. BCS scores of Group A were higher than those of Group B at 1, 2, 4, and 8h （P 〈0.05）, and BCS scores of Group C were lower than those of Group A and B at those hours（P 〈 0.05 ）. Conclusion： Parecoxib sodium used for preemptive analgesia in adult patients ungergoing nasal endoscope operations is effective and safe with less adverse drug reaction.