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甲基苯丙胺在成瘾与戒断大鼠体内分布比较

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摘要 目的比较甲基苯丙胺在成瘾与戒断后给药致死大鼠体内的分布情况。方法建立动物模型获得所需检材,经酸化水解后用环己烷提取,利用GC-MS全扫描定性分析,选择离子扫描定量分析。结果甲基苯丙胺在成瘾组脾、肺、眼中的含量明显低于戒断组;成瘾组心、肝、肾、脑、肌肉、睾丸中含量略高于戒断组;成瘾组肝中含量最高,戒断组脾中含量最高。成瘾组含量依次为:肝,脾,肾>心,肺>脑,肌肉,睾丸>眼球;戒断组含量依次为:肝,脾,肺,肾>心>脑,肌肉,睾丸>眼球。结论甲基苯丙胺在成瘾与戒断后给药致死大鼠体内的分布存在明显差异。
出处 《中国人民公安大学学报(自然科学版)》 2011年第1期9-11,共3页 Journal of People’s Public Security University of China(Science and Technology)
基金 公安部重点研究计划项目 项目编号:2009ZDYJBJSJ001
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