缓释性前列腺素E_2栓与米索前列醇在引产应用中的比较

Comparison of Prostaglandin E_2 in the Induction of Labor with Misoprostol

目的:比较延期妊娠孕妇阴道放置缓释性前列腺素E2栓(普贝生)与米索前列醇在引产中的应用情况。方法:选择我院86例单胎头位延期妊娠无引产禁忌症的孕妇,将其随意分成A、B两组,分别阴道放置缓释性前列腺素E_2栓(普贝生)与米索前列醇引产,并进行比较。结果:普贝生用于延期妊娠引产成功率高,不良反应少,易于放取,用药容易控制,时间短,安全性高;米索前列醇组引产有效且价格低廉、易保存,但剂量不易掌握,需多次阴道操作。两组在羊水污染率、剖宫产率、产后出血量、新生儿窒息等方面无统计学差异。结论:对于延期妊娠孕妇,特别是宫颈Bishop评分≤6分时,在排除胎儿、胎位、脐带、胎盘、羊水、产道异常的情况下,可以根据经济情况灵活应用缓释性前列腺素E_2栓(普贝生)与米索前列醇引产。但缓释性前列腺素E2栓引产成功率显著高于米索前列醇,宫颈Bishop评分提高快,引产成功时间也短于米索前列醇组。引产时应严格掌握适应证及禁忌证,遵循操作规程,注意监测胎心及宫缩情况。

Objective： Comparison of prolonged pregnancy of prostaglandin E2 in the induction of labor with misoprostol in application. Methods： Selecting our hospital 86 patients with single pregnancy, cephalic prolonged pregnancy without any vaginal delivery taboo were random divided into A and B groups. Prostaglandin E2 and misoprostol was put into the vaginal of pregnancy in this two groups separately. Results： There was more successful induction prolonged pregnancy rate,fewer side effects, easier to take, medication easier to control, safer and short time in using prostaglandin E2. While misoprostol induction of labor group was effectivly, easily to preserve and lower cost, but the dose was not easy to grasp,and vaginal operation to be repeated.Conclusion： For the prolonged pregnancy who were the exclusion of the fetus, fetal position, the umbilical cord, placenta, anmiotic fluid and the case of abnormal birth canal, in particular Bishop score 〈 6, they can be applied flexibly according to the economic situation of prostaglandin E2 with misoprostol induction of labor. But prostaglandin Ea is better than misoprostol in successful rate of labor induction,Bishop score and time. Induction of labor should be pay attention to the indications and contraindications, rules, fetal heart rate and contractions.