踝臂指数与冠心病患者冠状动脉病变的相关性研究

Relationship of Ankle-brachial Index and Severity of Coronary Atherosclerosis Lesions

目的:探讨踝臂指数(ABI)与冠脉病变严重程度的相关性。方法:根据冠状动脉造影(CAG)结果将967例患者分为CHD组(432例)和非CHD组(535例),均完善病史采集、血液生化检查及ABI检测。观察AB I对冠脉病变的预测价值。结果:(1)非冠心病(CHD)组与CHD组之间ABI异常率,比较差异有统计学意义(4.8%vs60.7%,P<0.001);CHD组的单支病变、双支病变、三支病变患者的ABI异常率,两两比较有统计学意义(P<0.05)。(2)CHD组的ABI值低于非CHD组(P<0.001),CHD组中的三支病变患者的ABI值低于单支病变组和双支病变组,两组比较差异有统计学意义(P<0.05)。(3)入选患者的Gensini评分与ABI呈显著负相关(r=-0.496,P<0.001)。结论:ABI与冠脉病变支数及程度密切相关,可作为冠脉病变严重程度的指标和用于CHD高危人群的筛查。

Objective：To explore the correlation of ankle-braehial index（ABI）and severity coronary atherosclerosis lesions.Methods： According to the coronary artery angiography ,967 patients were divided into coronary artery disease （CHD） groups（432cases） and no-CHD groups（535cases） ,All patient reeieved consummate history ,blood biochemistry and ABI tested,To observe the value of predict the severity of coronary atherosclerosis by ABI.Results：（1） The abnormal rate of ABI between Non-coronary heart disease （CHD） group and CHD group, was statistically significant （4.8% vs60.7%, P〈0.001）; In CHD group, the abnormal rate of ABI of single-vessel disease, double vessel disease and three vessel disease, with pairwise comparison, was statistically significant （P〈0.05）.（2） ABI values of CHD group lower than non-CHD group （P〈0.001）; In CHD group, ABI values of three lesions less than single vessel disease and double vessel disease, the difference was statistically significant （P〈0.05）.（3） Gensini score and ABI of the selected patients was negatively correlative （r=-0.496,P 〈0.001）.Conclusion：There is strong correlation between ABI and the severity of coronary atherosclerosis.And ABI may be helpful to predict the severity of coronary atherosclerosis and used for screening high risk population of CHD.