类风湿因子和抗环瓜酸抗体联合检测对类风湿关节炎的诊断价值及与疾病活动的相关性

Rheumatoid factor and anti-cyclic citrullinated peptides antibody in diagnosing significance in patients with rheumatoid arthritis and their correlation with disease activity

目的:比较类风湿因子(RF)和抗环瓜酸抗体(抗CCP抗体)在类风湿关节炎(RA)诊断及预测疾病活动性中的价值。方法:采用酶联免疫吸附法(ELISA)、速率散射比浊法检测RF和抗CCP抗体,比较它们单独或联合诊断RA的价值,分析RF和抗CCP抗体与疾病活动性的相关性。结果:RF和抗CCP抗体诊断RA的敏感性分别为81.5%和95.4%,特异性分别为58.8%和95.6%,联合诊断RA特异性增高;RF和抗CCP抗体均与C反应蛋白、红细胞沉降率显著相关。结论:RF联合抗CCP抗体应用可进一步提高RA的诊断准确性,RF和抗CCP抗体与RA疾病活动性密切相关。

Objective：To evaluate the diagnostic significance through detecting rheumatoid factor（RF-IgM） and anti-cyclic citrullinated peptide（CCP） antibody and their correlation with disease activity.Methods： We used enzyme-linked immunosorbent assay and rate nephelometry to detect CCP and RF in patients with 65 RA,68 non-RA.Results： The sensitivity for RF and anti-CCP were 81.5% and 95.4%,respectively,and the specificity were 58.8%,95.6%,respectively.The specificity was increased by combining the tests.A significant correlation was found between RF,anti-CCP and CRP,ESR,respectively.Conclusion： The higher specificity was achieved by combining the tests.There was an association between RF,anti-CCP and disease activity.