摘要
A number of salen-metal complexes were prepared and their enantioselective catalytic properties toward the asymmetric iodolactonization of （E）- and （Z）-5-substituted-4-pentenoic acid derivatives were investigated. The catalyst system based on salen-Co（II） complex exhibited moderate to good enantioselectivity with the e.e. value ranging from 53% to 74%, as well as high regioselectivity of δ- vs. γ-iodolactones. The salen-Co（II） complex showed the highest enantioselectivity on the asymmetric iodolactonizations of （Z）-5-substituted-4-pentenoic acid derivatives among these reagent-controlled iodolactonization protocols known so far.
A number of salen-metal complexes were prepared and their enantioselective catalytic properties toward the asymmetric iodolactonization of （E）- and （Z）-5-substituted-4-pentenoic acid derivatives were investigated. The catalyst system based on salen-Co（II） complex exhibited moderate to good enantioselectivity with the e.e. value ranging from 53% to 74%, as well as high regioselectivity of δ- vs. γ-iodolactones. The salen-Co（II） complex showed the highest enantioselectivity on the asymmetric iodolactonizations of （Z）-5-substituted-4-pentenoic acid derivatives among these reagent-controlled iodolactonization protocols known so far.
