α-酮酸片对维持性血液透析患者心脏功能和结构的影响

Effect of α-keto acid tablets on cardiac function and structure of patients undergoing hemodialysis

目的:探讨α-酮酸片(α-KA)对维持性血液透析(MHD)患者心脏功能和结构的影响。方法:观察30例α-酮酸片(商品名:开同)治疗组维持性血液透析患者与30例对照组患者,分别在治疗前及治疗6个月后超声心动图测定心脏结构指标:左房收缩末期内径(LADs)、左室舒张末期内径(LVEDd)、室间隔舒张末期厚度(IVSTd)、左室后壁舒张末期厚度(LVPWTd),左房内径指数(LAI)、左心室心肌重量指数(LVMI)、相对室壁厚度(RWT),心脏功能指标:左室射血分数(LVEF),左室短轴缩短率(FS),二尖瓣口舒张早期和晚期最大血流速度比(E/A)各项指标等检测,比较治疗前后各指标变化。结果:治疗组MHD患者心脏结构指标:左房收缩末期内径(LADs)、左室舒张末期内径(LVEDd)、室间隔舒张末期厚度(IVSTd)、左室后壁舒张末期厚度(LVPWTd),左房内径指数(LAI)、左心室心肌重量指数(LVMI)值均明显低于对照组,二者差异有显著性(P<0.05),两组相对室壁厚度(RWT)相比没有明显的差异(P>0.05)。心脏功能指标:左室射血分数(LVEF),左室短轴缩短率(FS),二尖瓣口舒张早期和晚期最大血流速度比(E/A)值较对照组明显增高(P<0.05),有统计学意义。结论:α-酮酸片可以改善MHD患者的心脏结构和功能,其对MHD患者心血管并发症的预防和治疗有一定临床指导意义。

Objective： To study the α-keto acid tablets（α-KA） on maintenance hemodialysis（MHD） patients with cardiac func-tion and structure.Methods： We observed 30 cases of α-keto acid tablets（brand name： Open the same） group of maintenance hemodialysis patients and 30 control patients,respectively,before treatment and 6 months after cardiac structure echocardiography Index： Left atrial end systolic diameter（LADs）,left ventricular end diastolic diameter（LVEDd）,interventricular septum diastolic thickness（IVSTd）,left ventricular posterior wall diastolic thickness（LVPWTd）,left atrial diameter index（LAI）,left ventricular mass index（LVMI）,relative wall thickness（RWT）,cardiac function parameters： left ventricular ejection fraction（LVEF）,left ventricular fractional shortening（FS）,mitral early and late diastolic peak velocity ratio（E / A） Detection of the indicators to compare before and after treatment were observed.Results： MHD patients with the treatment group cardiac structure indicators： left atrial end systolic diameter（LADs）,left ventricular end diastolic diameter（LVEDd）,interventricular septum diastolic thickness（IVSTd）,left ventricular posterior wall diastolic thickness（LVPWTd）,left atrial diameter index（LAI）,left ventricular mass index（LVMI） values were significantly lower than the control group,the difference was significant（P 0.05）,two relative wall thickness（RWT） no significant difference compared to（P 0.05）.Indicators of cardiac function： left ventricular ejection fraction（LVEF）,left ventricular fractional shortening（FS）,mitral early and late diastolic peak velocity ratio（E / A） value is significantly higher than the control group（P 0.05）,with statistical significance.Conclusions： α-keto acid tablets can improve the MHD patients with cardiac structure and function,and its cardiovascular complications in patients on MHD the prevention and treatment of certain clinical significance.