咳嗽变异性哮喘(CVA)与小气道功能相关性分析

Correlation Analysis of Cough Variant Asthma and Small Airway Function

目的:探讨咳嗽变异性哮喘(CVA)患者小气道功能检查对其诊断,治疗的意义。方法:对254例以慢性咳嗽为主的患者行肺功能检查并行支气管激发试验,回顾性分析小气道病变及气道高反应性检查结果与咳嗽变异性哮喘(CVA)的相关性。结果:有小气道功能障碍者接受吸入乙酰甲胆碱激发试验,气道反应性明显增高。有小气道功能障碍确诊咳嗽变异性哮喘(CVA)组起始阻力、反应阈值及阻力上升度与非哮喘组相比差异有统计学意义(P<0.01)。结论:检查小气道功能障碍有助于哮喘的诊断,治疗及预后随访。

Objective： To investigate the effect of the detection of small airway function of cough variant asthma patients（CVA） on the diagnosis,and treatment.Methods： The pulmonary function and bronchial provocation tests of 254 cases with chronic cough were detected.The relationship between the check airway lesions and small airway inspection results and cough variant asthma（CVA） was an-alyzed retrospectively.Results： Airway responsiveness increased obviously in the patients with little airway function of allergen-sensi-tized disabled and accepted inhaled methacholine provocation tests.There was little airway disorders diagnosed cough variant asthma（group） starting resistance,CVA reaction threshold and resistance of asthma and rise compared with that in the group（P 0.01）.Conclusion： The detection of tip small airway dysfunction can help the treatment and prognosis of asthma.