病理状态对肠寡肽转运体PEPT1活性的调节

Regulation of pathological state on activity of intestinal oligopeptide transporter PEPT1 in disease

PEPT1是位于小肠刷状缘膜的寡肽转运体,介导蛋白消化产物(如二肽和三肽)及类肽药物(如β-内酰胺类抗生素)的摄取和转运。营养不良及代谢失调(如高蛋白饮食、禁食和糖尿病)均可引起PEPT1基因和蛋白表达发生变化,一些临床常见病(如溃疡性结肠炎、克罗恩病、短肠综合征)也可诱导肠道PEPT1的表达和功能发生改变。检索PubMed数据库及参考互联网文献,并进行分析综述,探讨不同病理状态对PEPT1活性调节的机制,为患者的营养支持及药物治疗方案提供理论依据。

The oligopeptide transporter 1（PEPT1） is localized to the brush-border membrane and mediates the absorption and transportation of protein digestion products（i.g.dipeptides and tripeptides） and peptide-like drugs（i.g.β-lactam antibiotics）.Malnutrition and metabolic disordor（such as high-protein diet,fasting,and diabetes） could induce the modulation of protein and gene expressions of PEPT1.The intestinal diseases in clinic（such as ulcerative colitis,Cohn’s disease,and short-bowel syndrome） have shown the regulation of the PEPT1 expression and functional changes in their colon.Being analyzed and reviewed by searching PubMed Internet database and reference literature,some associated mechanisms of the regulation on PEPT1 activity by various pathological state have been studied to provide the theoretical basis for the nutritional support and pharmaceutical treatment programs.