温中和胃法改善乳癌化疗后迟发性恶心、呕吐的临床观察

Clinical Observation of Middle Warming Stomach Harmonizing on Vomit in Breast Cancer Patient following Chemotherapy

目的:探讨温中和胃法对乳腺癌化疗后延迟性呕吐的疗效和安全性。方法:采用随机对照的方法将100例患者分为治疗组(温中和胃法组)50例,对照组(昂丹司琼组)50例,分别在化疗后使用。观察治疗前后患者临床症状及心肝肾功能等。结果:迟发性恶心呕吐,治疗组总有效率为90%;对照组总有效率为72%。2组比较有显著性差异,P<0.05;卡氏评分指数显示,治疗组治疗后分值高于对照组,但无统计学意义,P>0.05。结论:以附子理中丸加味为代表的温中和胃法治疗化疗后迟发性恶心呕吐,取得了良好的效果,与西药昂丹司琼口服对比,具有疗效确切、治疗费用低廉、副反应少等优点,值得临床推广。

Objective：To investigate efficacy and safety of middle warming stomach harmonizing method for breast cancer patient,who present vomiting following chemotherapy. Methods：This is a randomized study：50 TCM method treated patients and 50 Ondansetron Hydrochloride Tablets treated patients,in terms of symptoms and heart,liver,kidney functions. Results：Effective rate for the treatment group was 90%,in comparison to that of control group 72% （P0.05）. Treatment group scored higher in KPS,not statistically significant. Conclusion：middle warming stomach harmonizing method,representing by Fuzi Middle harmonizing Decoction,has confirmed effect and safety for vomiting following chemotherapy in patient with breast cancer.