脑梗死患者幽门螺杆菌感染对血脂和超敏C反应蛋白的影响

Effect of Helicobacter pylori infection on plasma lipid and high sensitive C reactive protein levels in patients with cerebral infarction

目的探讨幽门螺杆菌（Hp）感染对脑梗死患者血脂和超敏C反应蛋白（hs-CRP）的影响，并探讨其发病机制。方法对确诊的79例脑梗死患者且近期无炎性反应性疾病，采用呼气试验来检测是否感染Hp，根据呼气试验将脑梗死患者分为感染阴性组15例、轻度感染组29例和重度感染组35例，后两者合称为感染阳性组，同时测定hs．CRP和血脂水平。结果与感染阴性组患者比较，感染阳性组患者总胆固醇、低密度脂蛋白及hs—CRP水平明显升高（P〈0．05）；重度感染组hs—CRP水平为（10．21±4．98）mg／L，明显高于轻度感染组的（5．81±4．21）mg／L（P=0．001）。结论Hp感染可能通过影响脂质代谢加重血管壁的炎性反应，导致更多的缺血性卒中事件发生，并随着感染程度加重，风险性亦相应增加。

Objective To investigate the effect of Helicobacter pylori （Hp） infection on plasma lipid and high sensitive C reactive protein （hs-CRP） levels in patients with cerebral infarction, and explore the pathogenesy. Methods Seventy-nine cerebral infarction patients without nearly inflammatory reaction disease were recruited. Hp was detected by breath test, the patients were divided into infection-negative group （ 15 cases）, light infection group （29 cases ） and severe infection group （35 cases ） according to the results, the last two groups were as infection-positive group. The plasma lipid and hs-CRP levels were examined. Results Compared with infection-negative group,the total cholesterol,low density lipoprotein,hs-CRP levels increased obviously in infection-positive group （P 〈 0.05 ）. The level of hs-CRP in severe infection group was higher than that in light infection group [ （10.21±4.98） mg/L vs. （5.81±4.21 ） mg/L] （P=0.001 ）. Conclusions Hp infection may increase vascular inflammatory reaction through lipid metabolic disturbance. The cerebral infarction with higher Hp infection, and with the degree of infection increased, the risk is also increased accordingly.