阿托伐他汀在原发性高血压患者中的临床应用

The clinical value of Atorvastatin in primary hypertensive patients

目的将阿托伐他汀应用于原发性高血压患者,观察其对血压和左心室肥厚的影响。方法选择120例原发性高血压患者随机分为对照组和观察组各60例。两组均给予氨氯地平5 mg/d,观察组加服阿托伐他汀20 mg/d治疗8周。同时测量两组治疗前后血压及左心室重量指数(LVM I)变化。结果与对照组相比,观察组收缩压、舒张压、脉压、左心室重量指数均显著降低(P<0.05)。结论阿托伐他汀可显著降低原发性高血压患者的血压、缩小脉压差,使降压更平稳,且能逆转左室肥厚。

Objective To observe the effect of blood pressure and left ventricular hypertrophy by the Atorvastatin in primary hypertensive patients.Methods 120 cases of primary hypertensive patients were randomly selected and divided equally into two groups：the control group and the observation group.In two groups,patients were treated by 5 mg/d Amlodipine treatment for 8 weeks.Additionally,observation group were treated by 20 mg/d Atorvastatin.The blood pressures and the left ventricular mass index（（LVMI）was measured before and after treatment in two groups.Results Compared with contrel group,blood pressure（SBP）,diastolic blood pressure（DBP）and PP decreased significantly（P〈0.05）in observatron group.Conclusion Atorvastatin can not only decreased the blood pressure,droped the pulse pressure,smoothly reduced and stabilized the blood pressure,but also induced the regression of left ventricular hypertrophy in primary hypertensive patients.