化疗后HBV的激活及拉米夫定的预防性应用

Preventive effect of Lamivudine and HBV reactivation of tumor patients with HBV infection after chemotherapy

目的观察拉米夫定对携带乙肝病毒(HBV)癌症患者化疗导致病毒重激活的预防及对肝功能的影响。方法预防组50例合并HBV感染的恶性肿瘤患者,对照组50例患者未接受拉米夫定治疗,观察两组化疗前后血清HBV DNA、肝功能的动态变化。结果化疗结束后的HBV激活率:对照组60%,预防组10%;化疗后肝炎发生率:对照组80%,预防组6%;两组差异有统计学意义(P<0.01)。结论预防性应用拉米夫定能明显减少化疗后HBV激活。

Objective To observe the preventive effect and liver function of Lamirudine effect to after chemotherapy HBV reaction of patients with HBV infection.Methods The prophylactic lamivudine group consisted of 50 patients who were treated with oral Lamivudine.The control group consisted of 50 patients who underwent chemotherapy without Lamivudine treatment.Serum HBVDNA level and liver function of all patients were examined before and after chemotherapy.Results The two groups appeared greatly diffrent：the rate of HBV reaction after chemotherapy：control group 60%and prophylactic group only 10%;the rate of hepatitis：control group 80% and prophylactic group 6%.There were difference between two groups（P〈0.01）.Conclusion Prophylactic using Lamivudine could obviously decrease HBV reaction of tumor patients with HBV infection after chemotherapy.