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GLP-1的生理作用及其机制研究进展 被引量：6

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摘要 近年来，以胰高糖素样肽1（Glucagon—like peptide-1，GLP-1）研究为基础的糖尿病新药成为糖尿病药物治疗领域的最大热点。与经典降糖药物相比，该类新药更少的低血糖发生率、降低空腹及餐后胰高血糖素、减轻体重、并在动物实验中证实能增加胰岛β细胞数量等诸多优点备受关注。
作者 陆珣靓 李成江
机构地区 浙江大学医学院附属第一医院内分泌科
出处 《浙江医学》 CAS 2011年第1期137-140,共4页 Zhejiang Medical Journal
关键词 GLP-1 生理作用 胰高糖素样肽 胰高血糖素 药物治疗 减轻体重 细胞数量 动物实验
分类号 R587.1 [医药卫生—内分泌]
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参考文献29

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  • 2Hjolund K R,Hughes T E,Deacon C F,et al.The dipeptidyl peptidase-4 inhibitor vildagliptin increases portal concentrations of active GLP-1 to a treater extent that the peripheral concentrations[J].Diabetologia,2008,57:A411.
  • 3Nakagawa A,Satake H,Nakabayashi H,et al.Receptor gene expression of glucagon-like peptide-1,but not glucosedependent insulinotropic polypeptide,in rat nodose ganglion cells[J].Auton Neurosci,2004,110(1):36-43.
  • 4Balkan B,Li X.GLP-1 administration in rats augments the insulin response to glucose via neuronal mechanisms[J].Am J Physiol Regul Integr Comp Phystol,2000 279(4):1449-1454.
  • 5Holst J J.Glucagon-like peptide-1:from extract to agent[J].The Claude Bernard Lecture,2006,49:253-260.
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  • 8Creutafdldt W O,Kleine N,Willms B,et al.Glucagonostatic actions and reduction of fasting hyperglycaemiaby exogenous glucagon-like peptide Ⅰ (7-36) amide in type Ⅰ diabetic patients[J].Diabetes Care,1996,19(6):580-586.
  • 9Naslund E,Bogefors J,Skogar S,et al.GLP-1 slows solid gastric emptying and inhibits insulin,glucagon,and PYY release in humans[J].Am J Physiol,1999,277:R910-916.
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同被引文献39

  • 1孙玉昆,伍登熙,朱志勇,等.促胰岛素分泌肽衍生物..中国:1363559[P].2002-08-14.
  • 2Ferrannini E, Mari A. beta-Cell function in type 2 diabetes [J]. Metabolism, 2014,63(10): 1217-1227.
  • 3Nadkarni P, Chepurny O G, Holz G G. Regulation of glucose homeostasis by G LP- 1 [J]. Prog Mol Biol Transl Sci, 2014,121:23- 65.
  • 4Nachnani J S, Bulchandani D G, Nookala A, et al. Biochemical and histological effects of exendin-4 (exenatide) on the rat pancreas [J]. Diabetologia, 2010,53(1):153-159.
  • 5Halban P A, Polonsky K S, Bowden D W, et al. beta-cell failure in type 2 diabetes: postulated mechanisms and prospects for pre- vention and treatment[J]. Diabetes Care, 2014,37(6): 1751 - 1758.
  • 6Campos C. Chronic hyperglycemia and glucose toxicity: patholo- gy and clinical sequelae[J]. Postgrad Med, 2012,124(6):90-97.
  • 7Kanda Y, Hashiramoto M, Shimoda M, et al. Dietary restriction preserves the mass and function of pancreatic beta cells via cell kinetic regulation and suppression of oxidative/ER stress in dia- betic mice[J]. J Nutr Biochem, 2014,26(3):219-226.
  • 8Zorov D B, Juhaszova M, Sollott S J. Mitochondrial reactive oxy- gen species(ROS)and ROS-induced ROS release[J]. Physiol Rev, 2014,94(3):909-950.
  • 9Aronson D. Hyperglycemia and the pathobiology of diabetic complications[J]. Adv Cardiol, 2008,45:1 - 16.
  • 10Wiederkehr A, Wollheim C B. Mitochondrial signals drive insulin secretion in the pancreatic beta-cell[J]. Mol Cell Endocrinol, 2012,353(1-2):128-137.

引证文献6

二级引证文献13

浙江医学
2011年 第1期

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