复方乌黄水凝胶的制备工艺

Preparation of Compound Wuhuang Hydrogel

目的:研究复方乌黄水凝胶的制备方法,优选工艺条件。方法:以复方乌黄水凝胶中乌头碱含量为指标,考察壳聚糖用量、海藻酸钠用量、交联时间、交联温度四个因素对复方乌黄水凝胶的制备工艺的影响。结果:壳聚糖,海藻酸钠,中药浸膏用量比例为2:6:1,交联40 min,交联温度30℃时水凝胶性能较好,并且凝胶中的乌头碱含量最高。结论:以壳聚糖为辅料,海藻酸钠为交联剂制成的水凝胶性能较好,载药量最大。

Objective： To prepare compound Wuhuang hydrogel and optimize the preparation process. Method： The content of aeonitine in the hydrogel as the index, the amount of chitosan and sodium algenate, crossing-linking time and temperature as the impact factors, the preparation process of compound Wuhuang hydrogel was optimized. Result： When the amount ratio of ehitosan, sodium algenate and extract was 2： 6： 1, cross-linking time was 40 minutes, and the cross-linking temperature was 30 ℃, the hydrogel performance was the best, and the content of aconitine in the hydrogel was the highest. Conclusion ： Chitosan as the base material and sodium algenate as the cross-linking agent, the hydrogel has promising properties and the drug loading is the highest.