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急性ST段抬高型心肌梗死患者口服药物变化的分析 被引量:5

Analysis of oral medication in patients with acute myocardial infarction
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摘要 目的 探讨近15年循证医学的发展对阿司匹林、β受体阻滞剂、他汀类药物、血管紧张素转换酶抑制剂(ACEI)/血管紧张素Ⅱ受体拈抗剂(ARB)在急性ST段抬高型心肌梗死(STEMI)患者住院期间使用比率的影响.方法 从1994年1月到2009年12月宣武医院心脏科住院的STEMI患者中选取初发且发病时限在24 h内的患者879例,按时间分为4组:1994年1月~1995年12月(A组)、1999年1月~2000年12月(B组)、2004年1月~2005年12月(C组)、2009年1月~12月(D组),分别对其临床诊治资料做回顾性分析.结果 近15年STEMI患者住院期间的阿司匹林使用率一直维持在97%以上,是4种药物中使用率最高的.β受体阻滞剂、他汀类药物、ACEI/ARB的使用率有了明显的上升,分别从1994年的37.9%、7.2%、25.3%上升为2009年的90.2%、95.5%、93.2%.结论 近15年,在循证医学的规范和指导下,阿司匹林、β受体阻滞剂、他汀类药物、血管紧张素转换酶抑制剂(ACEI)/血管紧张素Ⅱ受体拮抗剂(ARB)在STEMI中使用地位日益巩固. Objective To investigate the results of evidence-based medicine on use of aspirin, beta blockers, statin, angiotensin-converting enzyme inhibitors (ACEIs) /angiotensin receptor blockers (ARBs) in hospitalized patients with ST-segment elevation (STEMI) during 15 years. Methods Selected four groups of patients with acute myocardial infarction admitted to cardiology department of Xuanwu hospital between January 1994 and December 2009:1994. 1-1995.12 (group A), 1999. 1-2000. 12 (group B), 2004. 1 2005. 12-(group C), 2009. 12( group D). A total of 879 patients with STEMI whose emergency time within 24 hours were retrospectively analyzed. Results The utilization rate of aspirin in STEMI patients remained more than 97%, the highest utilization among four kinds of medicine. The in-hospital utilization rates of Beta blockers, statins, ACEI/ARB rose significantly: from 7.2%, 25.3%, 37.9% to 93.2%, 90.2%, 95.5% respectively during 15 years. Conclusion With the development of evidence-based medicine, the used status of aspirin, beta blockers, statins, ACEI/ARB in STEMI patients haveconsolidated in recently 15 years.
出处 《中国医药》 2011年第3期259-261,共3页 China Medicine
关键词 心肌梗死 药物治疗 分析 Acute myocardial infarction (AMI) Drug therapy Analyze
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  • 1陈韵岱,宋现涛,吕树铮,朱华刚,潘伟琦,宁尚秋,康铁朵.12小时内就诊的急性心肌梗死患者治疗现状分析[J].中国介入心脏病学杂志,2005,13(1):5-8. 被引量:67
  • 2Roth GJ,Majerus PW.The mechanism of the effect of aspirin on human platelets.I.Acetylation of a particulate fraction protein.J Clin Invest,1975,56(3):624-632.
  • 3高润霖.急性心肌梗死诊断和治疗指南[J].中华心血管病杂志,2001,29(12):710-725. 被引量:4952
  • 4Ferrari E,Benhamou M,Cerboni P,et al.Coronary syndromes following aspirin withdrawal:a special risk for late stent thrombosis.J Am Coll Cardiol,2005,45(3):456-459.
  • 5Califf RM,DeLong ER,Ostbye T,et al.Underuse of aspirin in a referral population with documented coronary artery disease.Am J Cardiol,2002,89 (6):653-661.
  • 6Weksler BB,Gillick M,Pink J.Effect of propranolol on platelet function.Blood,1977,49(2):185-196.
  • 7Madias JE,Shah B,Chintalapally G,et al.Admission serum potassium in patients with acute myocardial infarction:its correlates and value as a determinant of in-hospital outcome.Chest,2000,118(4):904-913.
  • 8Nuttall SL,Routledge HC,Kendall MJ.A comparison of the betal-selectivity of three betal-selective beta-blockers.J Clin Pharm Ther,2003,28(3):179-186.
  • 9陈跃峰,杨跃进,陈曦,阮英茆,孙瑞成,田毅,周燕文,王清峙,司文学,陈纪林,高润霖,陈在嘉.β受体阻滞剂阿替洛尔和酒石酸美托洛尔对大鼠急性心肌梗死后心肌细胞凋亡及凋亡相关基因表达的作用[J].中国医学科学院学报,2006,28(4):538-543. 被引量:5
  • 10Waagstein F,Strǒmblad O,Andersson B,et al.Increased exercise ejection fraction and reversed remodeling after long-term treatment with metoprolol in congestive heart failure:a randomized,stratified,double-blind,placebo-controlled trial in mild to moderate heart failure due to ischemic or idiopathic dilated cardiomyopathy.Eur J Heart Fail,2003,5 (5):679-691.

二级参考文献88

  • 1<血管紧张素转换酶抑制剂在肾脏病中正确应用>专家协会组.血管紧张素转换酶抑制剂在肾脏病中正确应用的专家共识[J].中华肾脏病杂志,2006,22(1):57-58. 被引量:69
  • 2Giuseppe DL, Harry S, Ottervanger JP, et al. Time delay to treatment and mortality in primary angioplasty for acute myocardial infarction.Circulation, 2004, 109.. 1223-1225.
  • 3Eagle KA, Goodman SG, Avecum A, et al. Practice variation and missed opportunities for reperfusian in ST-segment elevation myocardial infarction - findings from the Global Registry of Acute Coronary Events(GRACE). Lancet, 2002,359: 373-377.
  • 4Tamis-Holland JE, Palazzo A, Stebbins AL, et al. Benefits of direct angioplasty for women and man with acute myocardial infarction: results of the Global Use of Strategies to Open Occluded Arteries in Acute Coronary Syndromes Angioplasty (GUSTO H -B) Angioplasty Substudy.Am Heart J, 2004,147:133-139.
  • 5Giuseppe DL, Harry S, Felix Z, et al. Symptom-onset-to-balloon time and mortality in patients with acute myocardial infarction treated by primary angioplasty. J Am Coil Cardiol, 2003,42:991-997.
  • 6Cannon CP, Gibson CM, Lambrew CT, et al. Relationship of symptom-onset-to-balloon time and door-to-balloon time with mortality in patients undergoing angioplasty for acute myocardial infarction.JAMA, 2000,283:2941-2947.
  • 7Andersen HR., Nielsen TY, Rasmussen K, et al. Long distance transport for PCI vs immediate fibrinolysis in acute MI. DANAMI-2. N Engl J Med, 2002,349:733-742.
  • 8Grines CL, Westerhauson DR, Grines LL, et al. Transfer for primary PCI vs on site fibrinolysis in high risk ST-elevation MI patients. AIR PAM1. J Am Coil Cardiol, 2002,39:1713-1719.
  • 9Sam F,Sawyer DB,Chang DL,et al.Progressive left ventricular remodeling and apoptosis late after myocardial infarction in mouse heart.Am J Physiol Heart Circ Physiol,2000,279(1):H422-H428.
  • 10Palojoki E,Saraste A,Eriksson A,et al.Cardiomyocyte apoptosis and ventricular remodeling after myocardial infarction in rats.Am J Physiol Heart Circ Physiol,2001,280(6):H2726-H2731.

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