摘要
目的 探讨分析紫杉醇脂质体加顺铂诱导化疗后放疗治疗中晚期食管癌的疗效及不良反应.方法 将60例中晚期食管癌患者随机分为2组,即单纯放疗组和化放疗组,各30例.2组均采用6 MV X射线放射治疗,食管癌原发灶剂量60～70 Gy,B组紫杉醇脂质体135～175 mg/m2＋顺铂诱导化疗后给予放疗.评价2组近期（放疗结束时）与远期（随访1、3年）的疗效.结果 化放疗组放疗结束病变完全消退16例,完全消退率为53.3%;单纯放疗组完全消退14例,完全消退率为46.7%.2组近期疗效差异有统计学意义（P＜0.05）.单纯放疗组1、3年生存率分别为66.7%（20/30）、25.0%（7/30）;化放疗组1、3年生存率分别为79.2%（24/30）、58.3%（17/30）.2组远期疗效差异有统计学意义（均P＜0.05）.化放疗组出现放射性食管炎7例（Ⅰ度2例,Ⅱ度3例,Ⅲ度2例）,骨髓抑制9例（Ⅰ度4例,Ⅱ、Ⅲ度各2例,Ⅳ度1例）,恶心呕吐6例（Ⅰ度2例,Ⅱ度3例,Ⅲ度1例）.单纯放疗组出现放射性食管炎5例（Ⅰ、Ⅱ度各2例,Ⅲ度1例）,骨髓抑制4例（Ⅰ度3例,Ⅱ度1例）,恶心呕吐3例（Ⅰ度2例,Ⅱ度1例）.通过相应对症处理后2组均顺利完成放疗.结论 化放疗组可提高食管癌的无进展生存率和总生存率,不良反应有增加的趋势,均能耐受,不需中断放疗.
Objective To evaluate the efficacy and toxicity of paclitaxel and cisplatin chemoradiotherapy on local advanced esophageal cancer. Methods Totally 60 local advanced esophageal carcinoma patients were randomized into two groups. The first arm was radiotherapy only; The second arm was paclitaxel and platinol chemoradiotherapy. All patients were irradiated and the total radiation dose was 60 ～ 70 Gy in tumor. Results The overall responserates of radiotherapy arm and chemoradiotherapy arm was 73.34% and 88.66% respectively. There was a significant difference between the two arms （ P 〈 0.05 ）. The 1year and 3year overall survivalrate （OS） was 66.7% , 25.0%, 79.2%, 58.3% respectively. The OS had a significant difference between all arms （ P =0.041 ）.Conclusion Improved OS of locally advanced esophageal carcinoma can be achieved with paclitaxel and platinol chemoradiotherapy.
出处
《中国医药》
2011年第3期307-308,共2页
China Medicine
关键词
食管肿瘤
紫杉醇
脂质体
顺铂
Esophageal
Paclitaxel
Liposomes
Cisplatin
