注射用氯诺昔康与氟哌利多注射液配伍稳定性研究

Stability and compatibility of binary mixtures of lornoxicam with droperidol in 0.9% sodium chloride injection

目的 考察注射用氯诺昔康与氟哌利多注射液在0.9%氯化钠注射液中的配伍稳定性.方法 采用高效液相色谱法,测定注射用氯诺昔康与氟哌利多注射液配伍后在室温条件下72 h内的含量变化,并观察和检测配伍液的外观及pH变化.结果 氯诺昔康回归方程为Y氯=0.5477 X氯-0.4463（r=0.9996）;氟哌利多回归方程为Y氯=0.7406 X氟＋1.6857（r=0.9993）.氯诺昔康在10～120mg/L、氟哌利多在0.25～10mg/L浓度范围内线性关系良好.配伍液氯诺昔康含量与pH无明显变化,但氟哌利多的含量不断降低,并且配伍液6 h后出现白色针状沉淀.结论 注射用氯诺昔康与氟哌利多注射液在0.9%氯化钠注射液中不稳定,临床不宜配伍应用.

Objective To study the stability of the mixture of lornoxicam with droperidol in 0.9% sodium chloride injection. Methods The changes of the contents of lornoxicam and droperidol were determined simultaneously by HPLC, and pH value, the appearance of the solution was observed within 72 hours. Results No significant differences were found in the pH value and contents of lornoxicam, but the contents of droperidol steady decline with appearance of white needle-like precipitation during 6 hours. Conclusion The mixture of lornoxicam with droperidol injection in 0.9% sodium chloride injection at ambient temperature is not stable and clinical application is not compatible.