摘要
系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种以多种自身抗体产生和继发免疫复合物沉着为特点的系统性自身免疫性疾病,研究表明本病发生受遗传、激素和环境因素共同影响。近年研究证实,遗传因素在决定此病易感性及临床表型方面起关键作用,但是在不同种族、地区,SLE发病的易感基因及其影响程度有所不同。
systemic lupus erythematosus （SLE） is a systemic autoimmune disorder characterized by the production of broad variety of autoantibodies and subsequent immunecomplex deposition. Previous studies have suggested that genetic, hormonal, environmental factors contribute to the development of this disease. Several recent studies have further confirmed that genetic factor plays a critical role in determining the susceptibility and phenotype. The susceptible genes involved and the strength of their influence do, however, appear to differ considerably in different populations.
出处
《皮肤病与性病》
2011年第1期21-23,27,共4页
Dermatology and Venereology
关键词
系统性红斑狼疮
遗传易感性
研究
Systemic lupus erythematosus
Genetic susceptibility
