PDE5抑制剂对IVF中临时性ED患者的治疗效果及其对精液的影响

The effects of PDE5 inhibitors on temporary erectile dysfunction of patients undergoing in Vitro Fertilization and Its impact on sperm parameters

目的 探讨5型磷酸二酯酶（PDE5）抑制剂对常规体外受精（IVF）中临时性勃起功能障碍（ED）患者的治疗效果及其对精液的影响.方法 根据服用不同的PDE5抑制剂将89名临时性ED患者分为三组：他达拉非组、伐地那非组和西地那非组,观察患者获取精液的成功率,比较三组患者服药前1个月和服药后3h内的精液量、精液密度和精子活动力（a级＋b级）.结果 76（85.4%）名患者勃起功能改善,成功获取精液,三组患者的取精成功率差异无统计学意义（P〉0.05）;与服药前相比,三组患者服药后的精液量、精子密度及精子活动力差异无统计学意义（P〉0.05）.结论 PDE5抑制剂是治疗临时性ED患者的有效药物,PDE5抑制剂对IVF中临时性ED患者的精液参数无明显影响.

Objective To evaluate the effects ofPDE5 inhibitors on temporary erectile dysfunction of patients undergoing IVF and its impact on sperm parameters. Methods All 89 patients with temporary ED were divided into Tadalafil group, Vardenafil group and Sildenafil group according to adminstration of the different PDE5 inhibitors. Semen volume, sperm density and sperm motility （a＋b） were comparatively analyzed among three groups before and after using PDE5 inhibitors. Results In 89 patients with temporary ED, 76 patients （85.4%） improved their ejaculation function and had semen sucessfully. No significant difference was found in semen obtaining among three groups （P〉 0.05）. No significant differences were found in semen volume, sperm density and sperm motility among three groups before and after medication （P〉0.05）. Conclusion The PDE5 inhibitor was an effective medicine for treatment of temporary erectile dysfunction of patients undergoing IVF, and had no adverse effects on sperm parameters of patients.