原发性骨质疏松性椎体及股骨颈骨折病人血清基质金属蛋白酶-1与骨转换生化指标的关系

Relationship between serum MMP-1 level and ALP,NTX in patients with primary osteoporotic vertebral and femoral neck fracture

目的探讨原发性骨质疏松性椎体及股骨颈骨折病人血清基质金属蛋白酶-1(MMP-1)与骨转换生化指标血清碱性磷酸酶(ALP)及Ⅰ型胶原氨基末端肽(NTX)的关系。方法用酶联免疫吸附试验(ELISA)测定34名骨质疏松椎体及股骨颈骨折病人的血清MMP-1、血清ALP和血清Ⅰ型胶原氨基末端肽(sNTX)水平。结果原发性骨质疏松性椎体及股骨颈骨折患者血清MMP-1与ALP及NTX无相关性;患者血清NTX水平较年龄匹配的骨质疏松组增高(P<0.0 5),血清MMP-1水平高于年龄匹配的正常对照组及骨质疏松组(P<0.05)。结论血清NTX水平增高可能为骨折的危险因素。原发性骨质疏松性椎体及股骨颈骨折患者血清MMP-1水平升高,可能为高骨代谢转换过程中的一种生化表现。

Objective To study the relationship between serum matrix metalloproteinase-1（MMP-1） level and Serum alkaline phosphatase（ALP）,serum Cross-linked N-telopeptides of type I collagen（NTX） in patients with primary osteoporotic vertebral and femoral neck fracture.Methods Serum MMP-1,ALP and NTX were measured in 34 cases by ELISA.Results There was no significant correlation between MMP-1,ALP and NTX in primary osteoporotic vertebral and femoral neck fracture patients.Serum NTX was significantly higher in patients than in the age-matched patients with non-fracture osteoporosis（P〈0.05）.Serum MMP-1 was significantly higher in patients than in normal controls and patients with non-fracture osteoporosis（P〈0.05）.Conclusion Serum NTX may be a risk factor of osteoporotic vertebral and femoral neck fracture.Serum MMP-1 may be used as a bone turnover marker and a fracture risk factor in clinical diagnosis and treatment of osteoporosis patients.