大动脉弹性与老年退行性心瓣膜病的相关性研究

Study on arterial stiffness in patients with senile degenerative heart valvular disease

目的探讨大动脉弹性与老年退行性心瓣膜病(SDHVD)的相关性。方法选择SDHVD患者100例作为观察组,再根据瓣膜返流与否分为2个亚组,返流者46例,无返流54例,选择无SDHVD的同年龄组住院患者100例作为对照组。行脉搏波速度(PWV)检测,比较两组间PWV值和SDHVD及高血压、高脂血症、冠心病、糖尿病的发生率;以及PWV与瓣膜病变程度的相关性。结果 SDHVD组PWV>对照组,高血压、高脂血症的发生率也高于对照组(P<0.05);返流组PWV>无返流组(P<0.05);PWV与瓣膜病变严重程度呈正相关(P<0.05)。结论 SDHVD患者PWV明显增快,且与瓣膜严重程度呈正相关;大动脉弹性在评价SDHVD方面具有一定价值。

Objective To study on arterial stiffness in patients with senile degenerative heart valvular disease（SDHVD）.Methods 100 elderly patients with SDHVD were observed.They were divided in to two groups,46 patients with valvular regurgitation,54 patients with no valvular regurgitation（only degeneracy）,100 without valvular disease people were recruited as normal control.Pulse wave velocity（PWV） was measured among three groups,and relativities were analyzed between PWV and the degree of valvular disease.Results PWV in patients with SDHVD and the incidences of hypertension and hyperlipidemia were significantly higher than that in without valvular disease people（P〈0.05）;PWV in patients with valvular regurgitation was significantly higher than it was in no valvular regurgitation（only degeneracy）（P〈0.05）.Conclusion PWV was significantly increased with the SDHVD patients.There were significant positive correlations between them.The evaluation of PWV will be very applicable guidance for the diagnosis of SDHVD.