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NT-proBNP在呼吸困难鉴别中的应用研究 被引量:6

Application of NT-proBNP in the differential diagnosis of dyspnea which caused by heart disease or pulmonary disease
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摘要 目的探讨N末端脑钠肽(NT-proBNP)对心源性和肺源性呼吸困难的鉴别价值。方法用酶免疫分析法测定100例呼吸困难患者血浆中的NT-proBNP浓度,包括心源性呼吸困难和肺源性呼吸困难,观察两组患者血浆NT-proBNP的浓度。同时测定50例健康体检者的NT-proBNP浓度作为对照组做比较分析。结果两组患者的BNP浓度,心源性呼吸困难组(2 932.80±1 808.44)ng/L明显高于肺源性呼吸困难组(282.73±239.05)ng/L,两组差异有显著性意义(P<0.01)。结论 NT-proBNP可作为鉴别心源性呼吸困难和肺源性呼吸困难的一个客观指标,其方法简单快速、特异性好、敏感性高,具有显著的临床意义。 Objective To investigate the value of NT-proBNP in the differential diagnosis of dyspnea caused by heart disease or pulmonary disease.Methods The NT-proBNP of patients suffered from dyspnea which caused by heart failure or pulmonary disease were measured by immunoenzymometric assay and compared the results.Choose 50 health examples with medical examine as control group,and measured their plasma NT-proBNP level to make comparison analysis.Results The NT-proBNP level of the patients whose dyspnea were caused by heart disease(2932.80±1808.44)n/L were obviously higher than those of patients whose dyspnea were caused by pulmonary disease(282.73±239.05)n/L,there were significant differences between the two groups(P〈0.01).Conclusion NT-proBNP,which has remarkable clinical significance,can be used as the indicator in the differential diagnosis of dyspnea because of its highly sensitivity and specificity.
出处 《临床军医杂志》 CAS 2011年第1期129-131,共3页 Clinical Journal of Medical Officers
关键词 N末端脑钠肽 呼吸困难 心力衰竭 NT-proBNP dyspnea heart failure
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  • 1ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult[J].Circulation,2005,112 (4):154-235.
  • 2Morrison LK,Harrison A,Krishnaswamy P,et al.Utility of a rapid B-natriuretic peptide assay in differentiating congestive heart failure from lung disease in patients presenting with dyspnea[J].J Am Coll Cardiol,2002,39 (2):202-209.
  • 3崔喜梅,卫国红,荆小莉,廖晓星,李欣,熊艳,王西富.N末端脑钠肽对急性呼吸困难的鉴别诊断价值[J].中国急救医学,2007,27(7):601-602. 被引量:27
  • 4Nagagawa O,Ogawa Y,Itoh H,et al.Rapid transcriptional activation and early mRNA turnover of BNP in cardiaocyte hypertrophy.Evidence for BNP as an "emergency " cardiac hormone against vent ricular overload[J].J Clin Invest,1995,96 (3):1280-1287.
  • 5Maeda K,Tsutamota T,Wada A,et al.Plasma brain natriuretic peptide as a biochemical marker of high left ventricular end-diastolic pressure in patients with symptomatic left ventricular dysfunction[J].Am Heart J,1998,135:825-832.
  • 6李镛,顾学章.B-型利钠肽在肺科临床的应用[J].临床肺科杂志,2006,11(2):203-204. 被引量:24
  • 7Hunt PJ,Richards AM,Nicholls MG,et al.Immunoreactive aminoterminal pro-brain natriuretic peptide(NT-proBNP):A new marker for cardiac impairment[J].Clin Endocrinol,1997,47:287-296.
  • 8Mccullough PA,Nowak RM,Mccord J,et al.B-type natriuretic peptide and clinical judgment in emergency diagnosis of heart failure:analysis from breathing not properly (BNP) multinational study[J].Circulation,2002,106 (4):416-422.
  • 9史晓敏,林箐,徐国宾,宋以信,夏铁安.血清N末端B型钠尿肽原在心功能评价及慢性充血性心力衰竭诊断中的初步应用[J].中华检验医学杂志,2005,28(1):37-41. 被引量:77
  • 10Richards AM,Nicholls MG,Yandle TG,et al.Plasma N-terminal pro-brain natriureitc peptide and adrenomedullin:new neurohormonal predictors of left ventriculation function and prognosis after myocardial infarction[J].Circulation,1998,97:1921-1929.

二级参考文献26

  • 1史晓敏,宋以信,徐国宾,夏铁安.人血清N端脑钠肽水平参考值范围及其测定稳定性的初步调查[J].中国实验诊断学,2004,8(5):451-455. 被引量:18
  • 2张善春,刘兆昶.脑利钠肽在心力衰竭诊治中的研究进展[J].心血管病学进展,2005,26(1):43-46. 被引量:19
  • 3李镛,顾学章.B-型利钠肽在肺科临床的应用[J].临床肺科杂志,2006,11(2):203-204. 被引量:24
  • 4Hunt PJ, Richards AM, Nicholls MG, et al. Immunoreactive amino-terminal pro-brain natriuretic peptide (NT-PROBNP): a new marker of cardiac impairment. Clin Endocrinol, 1997, 47:287 -296.
  • 5Yeo KT , Wu AH , Apple FS, et al. Multicenter evaluation of the Roche NT-proBNP assay and comparison to the Biosite Triage BNP assay. Clin Chim Acta, 2003, 338:107-115.
  • 6Cowie MR, Struthers AD, Wood DA, et al. Value of natriuretic peptides in assessment of patients with possible new heart failure in primary care. Lancet, 1997, 350:1349-1353.
  • 7McDonagh TA, Robb SD, Murdoch DR, et al. Biochemical detection of left-ventricular systolic dysfunction. Lancet, 1998, 351:9-13.
  • 8Pfister R, Scholz M, Wielckens K, et al. Use of NT-proBNP in routing testing and comparison to BNP. Eur J Heart Fail, 2004, 6:289 -293.
  • 9Seino Y, Ogawa A, Yamashita T, et al. Application of NT-proBNP and BNP measurements in cardiac care: a more discerning marker for the detection and evaluation of heart failure. Eur J Heart Fail, 2004, 6:295-300.
  • 10McCullough PA, Sandberg KR. B-type natriuretic peptide and renal disease. Heart Fail Rev, 2003, 8:355 -358.

共引文献118

同被引文献29

  • 1李文强,魏捷,李艳,杨卫泽,万曦,周艳,王蕊.脑钠肽对急诊呼吸困难的鉴别诊断价值[J].中国急救医学,2005,25(3):178-180. 被引量:2
  • 2李卫鹏,郑佐娅,王红,王从珠,杭勤,赵卫国.氨基末端B型钠尿肽基因的克隆和原核表达载体的构建及纯化[J].检验医学,2005,20(5):405-408. 被引量:3
  • 3徐国宾,史晓敏.B型钠尿肽及N末端B型钠尿肽原在临床应用中值得关注的几个问题[J].中华检验医学杂志,2006,29(1):9-11. 被引量:71
  • 4许文荣,王建中.临床血液学与检验[M].4版.北京:人民卫生出版社,2008:259.
  • 5(美)[E.布朗威]EugeneBraunwald主编,陈灏珠主.心脏病学[M]人民卫生出版社,2000.
  • 6程兴海,王玲玲,阿荣娜.血清中PCT、STREM-1及乳酸测定在重症肺炎中的临床意义[J].中围实用医药,2013,8(13):55-56.
  • 7Martinez-Rumayor A, Richards AM, Bumett JC, et al. Biology of the natriuretie peptides [ J]. Am J Cardiol, 2008, 101 ( 3 A) : 3 -8.
  • 8Fclker GM, Petersen JW, Mark DB. Natriuretic peptides in the diagnosis and management of heart failure[ J]. CMAJ, 2006, 175(6) :611 -617.
  • 9Schou M, Dalsgaard MK, Clemmesen O, et al. Kidneys extract BNP and NT-proBNP in healthy young men[ J]. J Appl Physiol, 2005, 99(5) : 1676 -1680.
  • 10Christenson RH, Azzazy HM. Biochemical markers of the acute coronary syndromes[ J]. Clin Chem, 1998,44 : 1855 - 1864.

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