骨桥蛋白与骨质疏松症研究进展

Research Development of Osteopontin and Osteoporosis

骨桥蛋白作为一种新的细胞因子和趋化因子,在人体中发挥着重要作用,特别在骨代谢中作用尤为明显。骨桥蛋白可能刺激成骨细胞增殖、钙化,促进破骨细胞与骨基质的黏附并提高破骨细胞的溶骨活性,刺激骨吸收及骨重建,增加骨吸收陷窝的数量和面积,并抑制骨组织的矿化过程。

Osteopontin is an extensive existing cytokine and ehemotactic factor, and it plays an important role in human body, especially in bone metabolism. It may stimulate osteoblast proliferation and calcification, encourage osteoclast to adhere to bone matrix, enhance its osteolytic activity and inhibit bone mineralization.