林州筛查与非筛查人群食管/贲门癌患者生命质量评价

Assessment on Quality of Life for Patients with Esophageal or Cardiac Carcinoma Between Screening and Non-screening Group in Linzhou

[目的]对河南林州筛查组与对照组食管/贲门癌患者生命质量进行调查和评价,比较筛查组和对照组两组人群生命质量的差别,为"食管癌早诊早治"项目的开展提供科学依据。[方法]对2007～2009年筛查出的食管/贲门黏膜重度不典型增生及以上病变,并到河南林州肿瘤医院进行治疗的患者作为筛查组,而这3年自发去林州肿瘤医院治疗的食管/贲门黏膜重度不典型增生及以上病变的患者为对照组,其中筛查组124例,对照组98例,分别于治疗前、治疗后1个月、治疗后半年以及治疗后1年对调查对象采用自行设计的生命质量量表进行调查。采用描述性分析的方法,评价食管/贲门癌患者的生命质量情况,在不同调查时间比较两组的得分差异。[结果]筛查组在治疗前、治疗后1个月、治疗后半年以及1年生命质量平均总分均高于对照组且结果有统计学意义(P<0.05)。筛查组在治疗前、治疗后1个月、治疗后半年以及治疗后1年的总分平均为0.921±0.049、0.862±0.073、0.866±0.062和0.875±0.055,而对照组则分别为0.719±0.120、0.613±0.134、0.648±0.146和0.670±0.139。[结论]对食管癌高发地区40～69岁的高危人群进行食管/贲门癌的筛查及早诊早治对食管/贲门癌患者的生命质量大有益处。

[Purpose] To investigate and compare the quality of life （QOL） in patients with esophageal or cardiac carcinoma in the screening group and the control group in Linzhou City of Henan Province in order to solidify a scientific basis for the project of ＂Early Detection and Early Treatment for Esophageal Cancer＂（EDETEC）.[Methods] The screening group consisted of 124 patients who were identified as having severe dysplasia or more severe lesion of esophageal or cardiac mucosa through the screening program initiated from 2007 to 2009,while the control group was composed of 98 patients who were referred to the Linzhou Hospital with typical symptoms and diagnosed as having severe dysplasia or more severe lesion of esophageal or cardiac mucosa from 2007 to 2009.A QOL questionnaire for patients with esophageal or cardiac cancer was established to collect QOL data at different time points （prior to treatment,at 1 month,at 6 months and 1 year post-treatment）.Average QOL scores were calculated and compared between the screening group and the control group at different time points.[Results] The QOL scores in the screening group were significantly higher than those in the control group （P0.05）.The average QOL scores were 0.921±0.049,0.862±0.073,0.866±0.062 and 0.875±0.055 respectively in the screening group prior to treatment,at 1 month,6 months and 1 year post-treatment,with the scores of 0.719±0.120,0.613±0.134,0.648±0.146 and 0.670±0.139 respectively in the control group at corresponding time points.[Conclusion] The early detection and early treatment of esophageal or cardiac cancer （EDETEC） is beneficial to improve the QOL in high-risk population of 40 to 69 years old in high incidental area of esophaged cancer.